An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.

Wang X, Wen Z, Cao H, Luo J, Shuai L, Wang C, Ge J, Wang X, Bu Z, Wang J

Identification of bona fide functional receptors and elucidation of the mechanism of receptor-mediated virus entry are important to reveal targets for developing therapeutics against rabies virus (RABV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our previous studies suggest that metabotropic glutamate receptor subtype 2 (mGluR2) functions as an entry receptor for RABV in vitro, and is an important internalization ... [more]

J Virol Feb. 28, 2023; 97(2);e0161122 [Pubmed: 36779763]

Throughput

High Throughput

Additional Notes

Affinity capture-MS was carried out to identify high confidence protein interactors with the number of unique peptides being greater than or equal to 2 times over control in at least 2 replicates

Curated By

BioGRID

Interaction Summary

GRM2

Gene Ontology Biological Process

Gene Ontology Molecular Function

G-protein coupled receptor activity [TAS]calcium channel regulator activity [IBA]glutamate receptor activity [TAS]group II metabotropic glutamate receptor activity [IBA]

Gene Ontology Cellular Component

TSR1