ITPR1
Gene Ontology Biological Process
- calcium ion transmembrane transport [ISO]
- calcium ion transport [IDA]
- cellular response to cAMP [ISO]
- endoplasmic reticulum calcium ion homeostasis [IGI]
- inositol phosphate-mediated signaling [IDA, ISO]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- negative regulation of calcium-mediated signaling [ISO]
- negative regulation of neuron death [ISO]
- positive regulation of calcium ion transport [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- post-embryonic development [IMP]
- release of sequestered calcium ion into cytosol [IMP, ISO]
- response to hypoxia [IDA, ISO]
- voluntary musculoskeletal movement [IMP]
Gene Ontology Molecular Function- calcium channel inhibitor activity [ISO]
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO, TAS]
- intracellular ligand-gated calcium channel activity [IDA]
- phosphatidylinositol binding [IDA]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase binding [ISO]
- calcium channel inhibitor activity [ISO]
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO, TAS]
- intracellular ligand-gated calcium channel activity [IDA]
- phosphatidylinositol binding [IDA]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase binding [ISO]
Gene Ontology Cellular Component
- calcineurin complex [IDA]
- cell [IGI]
- cytoplasm [IDA, ISO]
- cytosol [IMP]
- dendrite [ISO]
- endoplasmic reticulum [IGI, TAS]
- endoplasmic reticulum membrane [IDA, ISO]
- intracellular [IMP]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- membrane raft [ISO]
- neuronal cell body [ISO]
- nuclear envelope [IDA, ISO]
- nuclear inner membrane [IDA]
- nucleolus [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- platelet dense granule membrane [ISO]
- platelet dense tubular network [ISO]
- postsynaptic density [IDA, ISO]
- protein complex [IPI, ISO]
- sarcoplasmic reticulum [IDA, ISO]
- secretory granule membrane [ISO]
- synaptic membrane [ISO]
HSPA9
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Loss of parkin causes endoplasmic reticulum calcium dyshomeostasis by upregulation of reticulocalbin 1.
Increasing evidence suggests that astrocytes play an important role in the progression of Parkinson's disease (PD). Previous studies on our parkin knockout mouse demonstrated a higher accumulation of damaged mitochondria in astrocytes than in surrounding dopaminergic (DA) neurons, suggesting that Parkin plays a crucial role regarding their interaction during PD pathogenesis. In the current study, we examined primary mesencephalic astrocytes ... [more]
Throughput
- Low Throughput
Additional Notes
- Proximity Ligation Assay (PLA)
Curated By
- BioGRID