BAIT

SLC6A8

CCDS1, CRT, CRTR, CT1, CTR5

solute carrier family 6 (neurotransmitter transporter), member 8

GO Process (7)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

cellular nitrogen compound metabolic process [TAS]

creatine metabolic process [TAS]

creatine transmembrane transport [NAS, TAS]

creatine transport [NAS]

muscle contraction [TAS]

small molecule metabolic process [TAS]

transport [TAS]

Gene Ontology Molecular Function

creatine transmembrane transporter activity [NAS]

Gene Ontology Cellular Component

integral component of membrane [TAS]

plasma membrane [TAS]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

LGALS3

CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2

lectin, galactoside-binding, soluble, 3

GO Process (18)

GO Function (5)

GO Component (9)

Gene Ontology Biological Process

eosinophil chemotaxis [IDA]

epithelial cell differentiation [IEP]

innate immune response [TAS]

macrophage chemotaxis [IDA]

monocyte chemotaxis [IDA]

mononuclear cell migration [IDA]

negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [ISS]

negative regulation of T cell receptor signaling pathway [ISS]

negative regulation of endocytosis [IDA]

negative regulation of extrinsic apoptotic signaling pathway [IDA]

negative regulation of immunological synapse formation [ISS]

neutrophil chemotaxis [IDA]

positive chemotaxis [IDA]

positive regulation of calcium ion import [IDA]

positive regulation of mononuclear cell migration [IDA]

regulation of T cell apoptotic process [IDA]

regulation of T cell proliferation [IMP]

regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]

Gene Ontology Molecular Function

IgE binding [IDA]
chemoattractant activity [IDA]
laminin binding [IDA]
poly(A) RNA binding [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

extracellular matrix [IDA]

extracellular space [IDA]

extracellular vesicular exosome [IDA]

immunological synapse [IDA]

mitochondrial inner membrane [IDA]

plasma membrane [TAS]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine Transporter SLC6A8.

Ferrada E, Wiedmer T, Wang WA, Frommelt F, Steurer B, Klimek C, Lindinger S, Osthushenrich T, Garofoli A, Brocchetti S, Bradberry S, Huang J, MacNamara A, Scarabottolo L, Ecker GF, Malarstig A, Superti-Furga G

Creatine is an essential metabolite for the storage and rapid supply of energy in muscle and nerve cells. In humans, impaired metabolism, transport, and distribution of creatine throughout tissues can cause varying forms of mental disability, also known as creatine deficiency syndrome (CDS). So far, 80 mutations in the creatine transporter (SLC6A8) have been associated to CDS. To better understand ... [more]

J Mol Biol Dec. 07, 2023; ();168383 [Pubmed: 38070861]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
SLC6A8 LGALS3	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Frommelt F (2025)	High	0.721	BioGRID	3821801

Curated By

BioGRID