BAIT

SLC6A8

CCDS1, CRT, CRTR, CT1, CTR5
solute carrier family 6 (neurotransmitter transporter), member 8
Homo sapiens
PREY

LMBR1

ACHP, C7orf2, DIF14, LSS, PPD2, THYP, TPT, ZRS, tcag7.573
limb development membrane protein 1
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine Transporter SLC6A8.

Ferrada E, Wiedmer T, Wang WA, Frommelt F, Steurer B, Klimek C, Lindinger S, Osthushenrich T, Garofoli A, Brocchetti S, Bradberry S, Huang J, MacNamara A, Scarabottolo L, Ecker GF, Malarstig A, Superti-Furga G

Creatine is an essential metabolite for the storage and rapid supply of energy in muscle and nerve cells. In humans, impaired metabolism, transport, and distribution of creatine throughout tissues can cause varying forms of mental disability, also known as creatine deficiency syndrome (CDS). So far, 80 mutations in the creatine transporter (SLC6A8) have been associated to CDS. To better understand ... [more]

J Mol Biol Dec. 07, 2023; ();168383 [Pubmed: 38070861]

Throughput

  • High Throughput

Curated By

  • BioGRID