BAIT
RECQL
RECQL1, RecQ1
RecQ helicase-like
GO Process (2)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
MYO6
DFNA22, DFNB37, RP3-472A9.1
myosin VI
GO Process (9)
GO Function (7)
GO Component (19)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator [IDA]
- actin filament-based movement [ISS, NAS]
- endocytosis [IMP, ISS]
- intracellular protein transport [ISS]
- membrane organization [TAS]
- metabolic process [ISS, NAS]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of secretion [IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- DNA-directed RNA polymerase II, holoenzyme [IDA]
- Golgi apparatus [IDA]
- cell cortex [ISS]
- clathrin-coated endocytic vesicle [IDA]
- cytoplasm [IDA, ISS]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytosol [TAS]
- endocytic vesicle [ISS]
- extracellular vesicular exosome [IDA]
- filamentous actin [IDA, ISS]
- lysosomal membrane [TAS]
- membrane [IDA]
- nuclear membrane [IDA]
- nucleoplasm [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA, ISS]
- plasma membrane [TAS]
- ruffle [IDA]
- unconventional myosin complex [TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.
Multiple myeloma (MM) is a plasma cell cancer with poor survival, characterized by the expansion of multiple myeloma cells (MMCs) in the bone marrow. Using a microarray-based genome-wide screen for genes responding to DNA methyltransferases (DNMT) inhibition in MM cells, we identified RECQ1 among the most downregulated genes. RecQ helicases are DNA unwinding enzymes involved in the maintenance of chromosome ... [more]
Leukemia Oct. 01, 2017; 31(10);2104-2113 [Pubmed: 28186131]
Throughput
- Low Throughput
Curated By
- BioGRID