BAIT
RNF130
G1RZFP, GOLIATH, GP
ring finger protein 130
GO Process (1)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
RAB7A
PRO2706, RAB7
RAB7A, member RAS oncogene family
GO Process (16)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- GTP catabolic process [IDA, TAS]
- Rab protein signal transduction [IBA]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- early endosome to late endosome transport [IMP]
- endocytosis [TAS]
- endosome to lysosome transport [IMP]
- epidermal growth factor catabolic process [IMP]
- phagosome acidification [IMP]
- phagosome maturation [TAS]
- phagosome-lysosome fusion [IMP]
- positive regulation of exosomal secretion [IMP]
- protein targeting to lysosome [IMP]
- protein to membrane docking [IDA]
- protein transport [TAS]
- regulation of autophagic vacuole assembly [IMP]
- retrograde transport, endosome to Golgi [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Evolutionarily conserved regulators of tau identify targets for new therapies.
Tauopathies are neurodegenerative diseases that involve the pathological accumulation of tau proteins; in this family are Alzheimer disease, corticobasal degeneration, and chronic traumatic encephalopathy, among others. Hypothesizing that reducing this accumulation could mitigate pathogenesis, we performed a cross-species genetic screen targeting 6,600 potentially druggable genes in human cells and Drosophila. We found and validated 83 hits in cells and further ... [more]
Neuron Mar. 15, 2023; 111(6);824-838.e7 [Pubmed: 36610398]
Quantitative Score
- 13.12 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Affinity capture MS was carried out to identify high confidence protein interactors
- log2(Fold, Target/Control) reported
Curated By
- BioGRID