BAIT
RNF130
G1RZFP, GOLIATH, GP
ring finger protein 130
GO Process (1)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
TRIM32
BBS11, HT2A, LGMD2H, TATIP, RP11-67K19.1
tripartite motif containing 32
GO Process (24)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- fat cell differentiation [ISS]
- innate immune response [IDA, TAS]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- negative regulation of viral release from host cell [IDA]
- negative regulation of viral transcription [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA, ISS]
- positive regulation of cell cycle [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell motility [ISS]
- positive regulation of neurogenesis [ISS]
- positive regulation of neuron differentiation [ISS]
- positive regulation of protein catabolic process [ISS]
- positive regulation of proteolysis [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of type I interferon production [TAS]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- regulation of type I interferon production [TAS]
- response to UV [ISS]
- response to tumor necrosis factor [ISS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Evolutionarily conserved regulators of tau identify targets for new therapies.
Tauopathies are neurodegenerative diseases that involve the pathological accumulation of tau proteins; in this family are Alzheimer disease, corticobasal degeneration, and chronic traumatic encephalopathy, among others. Hypothesizing that reducing this accumulation could mitigate pathogenesis, we performed a cross-species genetic screen targeting 6,600 potentially druggable genes in human cells and Drosophila. We found and validated 83 hits in cells and further ... [more]
Neuron Mar. 15, 2023; 111(6);824-838.e7 [Pubmed: 36610398]
Quantitative Score
- 9.97 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Affinity capture MS was carried out to identify high confidence protein interactors
- log2(Fold, Target/Control) reported
Curated By
- BioGRID