BAIT

PRKACA

PKACA
protein kinase, cAMP-dependent, catalytic, alpha
GO Process (38)
GO Function (6)
GO Component (9)

Gene Ontology Biological Process

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Fyn Regulates Binding Partners of Cyclic-AMP Dependent Protein Kinase A.

Schmoker AM, Barritt SA, Weir ME, Mann JE, Hogan TC, Ballif BA, Deming PB

The cAMP-dependent protein kinase A (PKA) is a serine/threonine kinase involved in many fundamental cellular processes, including migration and proliferation. Recently, we found that the Src family kinase Fyn phosphorylates the catalytic subunit of PKA (PKA-C) at Y69, thereby increasing PKA kinase activity. We also showed that Fyn induced the phosphorylation of cellular proteins within the PKA preferred target motif. ... [more]

Proteomes Sep. 29, 2018; 6(4); [Pubmed: 30274258]

Throughput

  • High Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
DNAJB6 PRKACA
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High-BioGRID
3354348

Curated By

  • BioGRID