Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells

GO Process (4)

GO Function (6)

GO Component (6)

Gene Ontology Biological Process

maintenance of cell polarity [IMP]

mitotic cytokinesis [IMP]

positive regulation of protein kinase activity [IDA]

septin ring assembly [IDA, IMP]

Gene Ontology Molecular Function

GTP binding [IDA]
GTPase activity [IDA]
phosphatidylinositol-4-phosphate binding [IDA]
phosphatidylinositol-5-phosphate binding [IDA]
protein complex scaffold [IMP]
structural molecule activity [IDA]

Gene Ontology Cellular Component

cellular bud neck septin ring [IDA]

cytoplasm [IDA]

mating projection [IDA]

prospore membrane [IDA]

septin complex [IDA, IPI]

septin filament array [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Protein interaction network revealed by quantitative proteomic analysis links TFIIB to multiple aspects of the transcription cycle.

O'Brien MJ, Ansari A

Although TFIIB is widely regarded as an initiation factor, recent reports have implicated it in multiple aspects of eukaryotic transcription. To investigate the broader role of TFIIB in transcription, we performed quantitative proteomic analysis of yeast TFIIB. We purified two different populations of TFIIB; one from soluble cell lysate, which is not engaged in transcription, and the other from the ... [more]

Biochim Biophys Acta Proteins Proteom Jan. 01, 2024; 1872(1);140968 [Pubmed: 37863410]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CDC12 SUA7	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2016)	High	-0.2087	BioGRID	1936658

Curated By

BioGRID

Interaction Summary

SUA7

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase II core binding [IDA, IPI]TBP-class protein binding [IDA, IPI]TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly [IDA, IMP]core RNA polymerase II recruiting transcription factor activity [IDA, IMP]

Gene Ontology Cellular Component

CDC12

Gene Ontology Biological Process

Gene Ontology Molecular Function

GTP binding [IDA]GTPase activity [IDA]phosphatidylinositol-4-phosphate binding [IDA]phosphatidylinositol-5-phosphate binding [IDA]protein complex scaffold [IMP]structural molecule activity [IDA]

Gene Ontology Cellular Component

Affinity Capture-MS

Publication

Protein interaction network revealed by quantitative proteomic analysis links TFIIB to multiple aspects of the transcription cycle.

Throughput

Related interactions

Curated By

RNA polymerase II core binding [IDA, IPI]
TBP-class protein binding [IDA, IPI]
TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly [IDA, IMP]
core RNA polymerase II recruiting transcription factor activity [IDA, IMP]

GTP binding [IDA]
GTPase activity [IDA]
phosphatidylinositol-4-phosphate binding [IDA]
phosphatidylinositol-5-phosphate binding [IDA]
protein complex scaffold [IMP]
structural molecule activity [IDA]