BAIT
GRIA1
GluA1, gluR-A
glutamate receptor, ionotropic, AMPA 1
GO Process (30)
GO Function (16)
GO Component (26)
Gene Ontology Biological Process
- cellular response to amine stimulus [IEP]
- cellular response to amino acid stimulus [IEP]
- cellular response to dsRNA [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to organic cyclic compound [IEP]
- cellular response to peptide hormone stimulus [IEP]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- long term synaptic depression [ISO]
- long-term memory [IMP, ISO]
- neuronal action potential [IMP]
- positive regulation of membrane potential [IMP]
- positive regulation of synaptic transmission [IMP]
- receptor internalization [IDA, ISO]
- regulation of receptor recycling [IMP]
- regulation of synaptic plasticity [IMP, NAS]
- regulation of synaptic transmission [IDA]
- response to arsenic-containing substance [IEP]
- response to cocaine [IEP]
- response to drug [IEP]
- response to electrical stimulus [IEP]
- response to estradiol [IEP]
- response to fungicide [IEP]
- response to lithium ion [IEP]
- response to organic cyclic compound [IEP]
- response to peptide hormone [IEP]
- response to toxic substance [IMP]
- spinal cord development [IEP]
- synaptic transmission [ISO]
- synaptic transmission, glutamatergic [NAS]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [IPI]
- G-protein beta-subunit binding [IDA]
- PDZ domain binding [IPI]
- adenylate cyclase binding [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, ISO]
- beta-2 adrenergic receptor binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA]
- myosin V binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [TAS]
- protein kinase A binding [IDA]
- protein kinase binding [IPI]
- small GTPase binding [IPI]
- G-protein alpha-subunit binding [IPI]
- G-protein beta-subunit binding [IDA]
- PDZ domain binding [IPI]
- adenylate cyclase binding [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, ISO]
- beta-2 adrenergic receptor binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA]
- myosin V binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [TAS]
- protein kinase A binding [IDA]
- protein kinase binding [IPI]
- small GTPase binding [IPI]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [IDA]
- axonal spine [ISO]
- cell surface [IDA, ISO]
- cytosol [IDA]
- dendrite [ISO, ISS]
- dendrite membrane [ISO]
- dendritic shaft [IDA]
- dendritic spine [IDA, ISO]
- dendritic spine membrane [ISO]
- early endosome [IDA]
- endoplasmic reticulum [ISO]
- excitatory synapse [IDA]
- ionotropic glutamate receptor complex [ISO, TAS]
- membrane [ISO]
- neuromuscular junction [IDA]
- neuron projection [IDA, ISO]
- neuron spine [IDA, ISO]
- neuronal cell body [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- protein complex [IDA]
- recycling endosome [ISO]
- synapse [IDA, IMP, ISO]
- synaptic vesicle [ISO]
Rattus norvegicus
PREY
GRIA1
GluA1, gluR-A
glutamate receptor, ionotropic, AMPA 1
GO Process (30)
GO Function (16)
GO Component (26)
Gene Ontology Biological Process
- cellular response to amine stimulus [IEP]
- cellular response to amino acid stimulus [IEP]
- cellular response to dsRNA [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to organic cyclic compound [IEP]
- cellular response to peptide hormone stimulus [IEP]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- long term synaptic depression [ISO]
- long-term memory [IMP, ISO]
- neuronal action potential [IMP]
- positive regulation of membrane potential [IMP]
- positive regulation of synaptic transmission [IMP]
- receptor internalization [IDA, ISO]
- regulation of receptor recycling [IMP]
- regulation of synaptic plasticity [IMP, NAS]
- regulation of synaptic transmission [IDA]
- response to arsenic-containing substance [IEP]
- response to cocaine [IEP]
- response to drug [IEP]
- response to electrical stimulus [IEP]
- response to estradiol [IEP]
- response to fungicide [IEP]
- response to lithium ion [IEP]
- response to organic cyclic compound [IEP]
- response to peptide hormone [IEP]
- response to toxic substance [IMP]
- spinal cord development [IEP]
- synaptic transmission [ISO]
- synaptic transmission, glutamatergic [NAS]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [IPI]
- G-protein beta-subunit binding [IDA]
- PDZ domain binding [IPI]
- adenylate cyclase binding [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, ISO]
- beta-2 adrenergic receptor binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA]
- myosin V binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [TAS]
- protein kinase A binding [IDA]
- protein kinase binding [IPI]
- small GTPase binding [IPI]
- G-protein alpha-subunit binding [IPI]
- G-protein beta-subunit binding [IDA]
- PDZ domain binding [IPI]
- adenylate cyclase binding [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, ISO]
- beta-2 adrenergic receptor binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA]
- myosin V binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [TAS]
- protein kinase A binding [IDA]
- protein kinase binding [IPI]
- small GTPase binding [IPI]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [IDA]
- axonal spine [ISO]
- cell surface [IDA, ISO]
- cytosol [IDA]
- dendrite [ISO, ISS]
- dendrite membrane [ISO]
- dendritic shaft [IDA]
- dendritic spine [IDA, ISO]
- dendritic spine membrane [ISO]
- early endosome [IDA]
- endoplasmic reticulum [ISO]
- excitatory synapse [IDA]
- ionotropic glutamate receptor complex [ISO, TAS]
- membrane [ISO]
- neuromuscular junction [IDA]
- neuron projection [IDA, ISO]
- neuron spine [IDA, ISO]
- neuronal cell body [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- protein complex [IDA]
- recycling endosome [ISO]
- synapse [IDA, IMP, ISO]
- synaptic vesicle [ISO]
Rattus norvegicus
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
The Transmembrane Domain Mediates Tetramerization of ?-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors.
AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the central nervous system. Functional AMPARs are tetrameric complexes with a highly modular structure, consisting of four evolutionarily distinct structural domains: an amino-terminal domain (ATD), a ligand-binding domain (LBD), a channel-forming transmembrane domain (TMD), and a carboxyl-terminal domain (CTD). Here we show that the isolated TMD of the GluA1 AMPAR is fully ... [more]
J Biol Chem Mar. 18, 2016; 291(12);6595-606 [Pubmed: 26839312]
Throughput
- Low Throughput
Curated By
- BioGRID