GRIA2
Gene Ontology Biological Process
- establishment of protein localization [IMP]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IBA, ISO, ISS]
- positive regulation of synaptic transmission [IMP]
- protein tetramerization [IDA]
- receptor internalization [IDA]
- regulation of receptor recycling [IMP]
- regulation of synaptic transmission, glutamatergic [IMP]
- response to fungicide [IEP]
- response to lithium ion [IEP]
- synaptic transmission [IDA, ISO]
Gene Ontology Molecular Function- PDZ domain binding [IDA, IPI]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, TAS]
- calcium channel regulator activity [TAS]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA, ISO, TAS]
- kainate selective glutamate receptor activity [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- receptor activity [IDA]
- PDZ domain binding [IDA, IPI]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, TAS]
- calcium channel regulator activity [TAS]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA, ISO, TAS]
- kainate selective glutamate receptor activity [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- receptor activity [IDA]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [IDA]
- cell surface [IDA]
- dendrite [IDA]
- dendrite cytoplasm [IDA]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- endoplasmic reticulum [ISO]
- growth cone [IDA]
- integral component of plasma membrane [IDA]
- ionotropic glutamate receptor complex [TAS]
- membrane [ISO]
- neuron projection [ISO]
- neuronal cell body [IDA]
- perikaryon [IDA]
- postsynaptic density [IDA]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IDA]
- protein complex [IDA, IPI]
- synapse [IDA, ISO]
- synaptic vesicle [ISO]
- synaptic vesicle membrane [IDA]
- terminal bouton [IDA]
GRIA2
Gene Ontology Biological Process
- establishment of protein localization [IMP]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IBA, ISO, ISS]
- positive regulation of synaptic transmission [IMP]
- protein tetramerization [IDA]
- receptor internalization [IDA]
- regulation of receptor recycling [IMP]
- regulation of synaptic transmission, glutamatergic [IMP]
- response to fungicide [IEP]
- response to lithium ion [IEP]
- synaptic transmission [IDA, ISO]
Gene Ontology Molecular Function- PDZ domain binding [IDA, IPI]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, TAS]
- calcium channel regulator activity [TAS]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA, ISO, TAS]
- kainate selective glutamate receptor activity [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- receptor activity [IDA]
- PDZ domain binding [IDA, IPI]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, TAS]
- calcium channel regulator activity [TAS]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA, ISO, TAS]
- kainate selective glutamate receptor activity [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- receptor activity [IDA]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [IDA]
- cell surface [IDA]
- dendrite [IDA]
- dendrite cytoplasm [IDA]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- endoplasmic reticulum [ISO]
- growth cone [IDA]
- integral component of plasma membrane [IDA]
- ionotropic glutamate receptor complex [TAS]
- membrane [ISO]
- neuron projection [ISO]
- neuronal cell body [IDA]
- perikaryon [IDA]
- postsynaptic density [IDA]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IDA]
- protein complex [IDA, IPI]
- synapse [IDA, ISO]
- synaptic vesicle [ISO]
- synaptic vesicle membrane [IDA]
- terminal bouton [IDA]
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
Probing Intersubunit Interfaces in AMPA-subtype Ionotropic Glutamate Receptors.
AMPA subtype ionotropic glutamate receptors (iGluRs) mediate the majority of fast neurotransmission across excitatory synapses in the central nervous system. Each AMPA receptor is composed of four multi-domain subunits that are organized into layers of two amino-terminal domain (ATD) dimers, two ligand-binding domain (LBD) dimers, transmembrane domains and carboxy-terminal domains. We introduced cysteine substitutions at the intersubunit interfaces of AMPA ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRIA2 GRIA2 | Co-crystal Structure Co-crystal Structure Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex. | Low | - | BioGRID | 3674864 | |
| GRIA2 GRIA2 | Co-crystal Structure Co-crystal Structure Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex. | Low | - | BioGRID | 3673843 |
Curated By
- BioGRID