MCAM
Gene Ontology Biological Process
Gene Ontology Cellular Component
STX7
Gene Ontology Biological Process
- intracellular protein transport [IBA]
- organelle assembly [IDA]
- organelle localization [IDA]
- positive regulation of T cell mediated cytotoxicity [IMP]
- positive regulation of receptor localization to synapse [IMP]
- regulation of protein localization to plasma membrane [IDA]
- vesicle docking [IBA]
- vesicle fusion [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SNARE complex [IBA]
- azurophil granule [IDA]
- early endosome [IDA]
- endocytic vesicle [IDA]
- endomembrane system [IBA]
- endosome [IDA]
- extracellular vesicular exosome [IDA]
- immunological synapse [IDA]
- integral component of membrane [IBA]
- intracellular membrane-bounded organelle [IDA]
- late endosome [IDA]
- lysosomal membrane [IDA]
- lysosome [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- recycling endosome [IDA]
- tertiary granule [IDA]
- vesicle [IDA]
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.
The WRAMP structure is a protein network associated with tail-end actomyosin contractility, membrane retraction, and directional persistence during cell migration. A marker of WRAMP structures is melanoma cell adhesion molecule (MCAM) which dynamically polarizes to the cell rear. However, factors that mediate MCAM polarization are still unknown. In this study, BioID using MCAM as bait identifies the ERM family proteins, ... [more]
Throughput
- High Throughput
Additional Notes
- BioID
- Samples with a SAINT score corresponding to an FDR less than 0.05 were considered significant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STX7 MCAM | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 60 | BioGRID | 3008366 |
Curated By
- BioGRID