BAIT

MCAM

CD146, MUC18
melanoma cell adhesion molecule
GO Process (4)
GO Function (0)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens
PREY

WLS

C1orf139, EVI, GPR177, MRP, mig-14, RP11-518D3.2
wntless Wnt ligand secretion mediator
GO Process (2)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.

Miller SG, Hoh M, Ebmeier CC, Tay JW, Ahn NG

The WRAMP structure is a protein network associated with tail-end actomyosin contractility, membrane retraction, and directional persistence during cell migration. A marker of WRAMP structures is melanoma cell adhesion molecule (MCAM) which dynamically polarizes to the cell rear. However, factors that mediate MCAM polarization are still unknown. In this study, BioID using MCAM as bait identifies the ERM family proteins, ... [more]

Mol Biol Cell Dec. 20, 2023; ();mbcE23060255 [Pubmed: 38117590]

Throughput

  • High Throughput

Additional Notes

  • BioID
  • Samples with a SAINT score corresponding to an FDR less than 0.05 were considered significant

Curated By

  • BioGRID