BAIT
SSTR3
Smstr-3, Smstr3, sst3
somatostatin receptor 3
GO Process (9)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [IBA]
- behavior [IBA]
- cellular response to estradiol stimulus [IBA]
- cellular response to glucocorticoid stimulus [IBA]
- negative regulation of cell proliferation [IBA]
- neuropeptide signaling pathway [IBA]
- regulation of insulin secretion [IBA]
- somatostatin signaling pathway [IBA]
- synaptic transmission [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HTR2A
E030013E04, Htr-2, Htr2
5-hydroxytryptamine (serotonin) receptor 2A
GO Process (32)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- activation of phospholipase C activity [ISO]
- artery smooth muscle contraction [ISO]
- behavioral response to cocaine [ISO]
- cell death [ISO]
- cellular calcium ion homeostasis [ISO]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- detection of temperature stimulus involved in sensory perception of pain [ISO]
- memory [ISO]
- negative regulation of potassium ion transport [ISO]
- negative regulation of synaptic transmission, glutamatergic [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- phospholipase C-activating serotonin receptor signaling pathway [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of fat cell differentiation [IMP]
- positive regulation of glycolytic process [IMP]
- positive regulation of kinase activity [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of phosphatidylinositol biosynthetic process [ISO]
- positive regulation of vasoconstriction [ISO]
- protein localization to cytoskeleton [IDA]
- regulation of dopamine secretion [ISO]
- release of sequestered calcium ion into cytosol [ISO]
- response to drug [ISO]
- sensory perception of pain [ISO]
- serotonin receptor signaling pathway [ISO]
- sleep [ISO]
- temperature homeostasis [ISO]
- urinary bladder smooth muscle contraction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.
Primary cilia are conserved sensory hubs essential for signaling transduction and embryonic development. Ciliary dysfunction causes a variety of developmental syndromes with neurological features and cognitive impairment, whose basis mostly remains unknown. Despite connections to neural function, the primary cilium remains an overlooked organelle in the brain. Most neurons have a primary cilium; however, it is still unclear how this ... [more]
bioRxiv Dec. 21, 2023; (); [Pubmed: 38187761]
Throughput
- High Throughput
Additional Notes
- BioID
- Proteins were considered hits if they showed at least a 2-fold enrichment in GPCRs-BirA2 compared to BirA alone, and a false discovery rate of at least 0.7 (p-value of 0.036 or lower)
Curated By
- BioGRID