BAIT
SSTR3
Smstr-3, Smstr3, sst3
somatostatin receptor 3
GO Process (9)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [IBA]
- behavior [IBA]
- cellular response to estradiol stimulus [IBA]
- cellular response to glucocorticoid stimulus [IBA]
- negative regulation of cell proliferation [IBA]
- neuropeptide signaling pathway [IBA]
- regulation of insulin secretion [IBA]
- somatostatin signaling pathway [IBA]
- synaptic transmission [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PLCB1
3110043I21Rik, AI132408, Plcb, mKIAA0581, RP23-418D21.3
phospholipase C, beta 1
GO Process (36)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [IMP]
- G2/M transition of mitotic cell cycle [IDA, NAS]
- activation of meiosis involved in egg activation [IDA]
- brain development [NAS]
- cell adhesion [IC]
- cerebral cortex development [IMP]
- erythrocyte differentiation [TAS]
- fat cell differentiation [IDA]
- glutamate receptor signaling pathway [IMP]
- insulin receptor signaling pathway [TAS]
- insulin-like growth factor receptor signaling pathway [IDA]
- interleukin-1-mediated signaling pathway [ISO]
- interleukin-12-mediated signaling pathway [ISO]
- interleukin-15-mediated signaling pathway [ISO]
- mRNA processing [TAS]
- macrophage differentiation [NAS]
- memory [IMP]
- negative regulation of monocyte extravasation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- oocyte maturation [NAS]
- positive regulation of CD24 biosynthetic process [IDA]
- positive regulation of G1/S transition of mitotic cell cycle [IDA]
- positive regulation of GTPase activity [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of acrosome reaction [IMP]
- positive regulation of developmental growth [IMP]
- positive regulation of embryonic development [IMP]
- positive regulation of interleukin-12 production [IMP]
- positive regulation of myoblast differentiation [IDA]
- positive regulation of sodium:proton antiporter activity [NAS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of G-protein coupled receptor protein signaling pathway [IMP]
- regulation of fertilization [IMP]
- response to monosaccharide [ISO]
- response to peptide hormone [ISO]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.
Primary cilia are conserved sensory hubs essential for signaling transduction and embryonic development. Ciliary dysfunction causes a variety of developmental syndromes with neurological features and cognitive impairment, whose basis mostly remains unknown. Despite connections to neural function, the primary cilium remains an overlooked organelle in the brain. Most neurons have a primary cilium; however, it is still unclear how this ... [more]
bioRxiv Dec. 21, 2023; (); [Pubmed: 38187761]
Throughput
- High Throughput
Additional Notes
- BioID
- Proteins were considered hits if they showed at least a 2-fold enrichment in GPCRs-BirA2 compared to BirA alone, and a false discovery rate of at least 0.7 (p-value of 0.036 or lower)
Curated By
- BioGRID