BAIT
SSTR3
Smstr-3, Smstr3, sst3
somatostatin receptor 3
GO Process (9)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [IBA]
- behavior [IBA]
- cellular response to estradiol stimulus [IBA]
- cellular response to glucocorticoid stimulus [IBA]
- negative regulation of cell proliferation [IBA]
- neuropeptide signaling pathway [IBA]
- regulation of insulin secretion [IBA]
- somatostatin signaling pathway [IBA]
- synaptic transmission [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
GABBR1
GABAB1, GABAbR1, bM573K1.1
gamma-aminobutyric acid (GABA) B receptor, 1
GO Process (13)
GO Function (3)
GO Component (18)
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [ISO]
- gamma-aminobutyric acid signaling pathway [IDA, ISO]
- negative regulation of adenylate cyclase activity [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of dopamine secretion [ISO]
- negative regulation of epinephrine secretion [ISO]
- negative regulation of gamma-aminobutyric acid secretion [ISO]
- negative regulation of synaptic transmission [ISO]
- osteoblast differentiation [ISO]
- positive regulation of glutamate secretion [ISO]
- positive regulation of growth hormone secretion [ISO]
- regulation of cAMP biosynthetic process [ISO]
- regulation of glutamate secretion [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- G-protein coupled receptor dimeric complex [IDA]
- G-protein coupled receptor heterodimeric complex [ISO]
- axolemma [ISO]
- cytoplasm [IDA]
- dendritic shaft [ISO]
- dendritic spine [ISO]
- endoplasmic reticulum membrane [ISO]
- extracellular space [ISO]
- integral component of plasma membrane [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane [IDA]
- membrane raft [ISO]
- mitochondrial membrane [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- postsynaptic membrane [IDA]
- presynaptic membrane [IDA]
- synaptic vesicle [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.
Primary cilia are conserved sensory hubs essential for signaling transduction and embryonic development. Ciliary dysfunction causes a variety of developmental syndromes with neurological features and cognitive impairment, whose basis mostly remains unknown. Despite connections to neural function, the primary cilium remains an overlooked organelle in the brain. Most neurons have a primary cilium; however, it is still unclear how this ... [more]
bioRxiv Dec. 21, 2023; (); [Pubmed: 38187761]
Throughput
- High Throughput
Additional Notes
- BioID
- Proteins were considered hits if they showed at least a 2-fold enrichment in GPCRs-BirA2 compared to BirA alone, and a false discovery rate of at least 0.7 (p-value of 0.036 or lower)
Curated By
- BioGRID