BAIT
SSTR3
Smstr-3, Smstr3, sst3
somatostatin receptor 3
GO Process (9)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [IBA]
- behavior [IBA]
- cellular response to estradiol stimulus [IBA]
- cellular response to glucocorticoid stimulus [IBA]
- negative regulation of cell proliferation [IBA]
- neuropeptide signaling pathway [IBA]
- regulation of insulin secretion [IBA]
- somatostatin signaling pathway [IBA]
- synaptic transmission [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ITGB1
4633401G24Rik, AA409975, AA960159, CD29, ENSMUSG00000051907, Fnrb, Gm9863, gpIIa
integrin beta 1 (fibronectin receptor beta)
GO Process (47)
GO Function (18)
GO Component (34)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- axon extension [IGI, IMP]
- calcium-independent cell-matrix adhesion [ISO]
- cardiac muscle cell differentiation [IMP]
- cardiac muscle tissue development [IMP]
- cell adhesion [ISO]
- cell fate specification [IMP]
- cell migration [IMP]
- cell migration involved in sprouting angiogenesis [IMP]
- cell-matrix adhesion [IGI, IMP, ISO]
- cell-substrate adhesion [ISO]
- cellular calcium ion homeostasis [ISO]
- dendrite morphogenesis [IGI, IMP]
- formation of radial glial scaffolds [IMP]
- germ cell migration [IMP]
- heterotypic cell-cell adhesion [ISO]
- in utero embryonic development [IMP]
- integrin-mediated signaling pathway [ISO]
- leukocyte cell-cell adhesion [ISO]
- leukocyte tethering or rolling [ISO]
- negative regulation of Rho protein signal transduction [IGI]
- negative regulation of anoikis [ISO]
- negative regulation of cell differentiation [IMP]
- negative regulation of cell projection organization [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of neuron differentiation [ISO]
- neuron projection development [IMP]
- positive regulation of MAPK cascade [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of neuron differentiation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- protein transport within lipid bilayer [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- regulation of cell cycle [IMP]
- regulation of collagen catabolic process [ISO]
- sarcomere organization [IMP]
- stress fiber assembly [IMP]
- tight junction assembly [ISO]
- tissue homeostasis [ISO]
- transforming growth factor beta receptor signaling pathway [IMP]
- visual learning [IGI, IMP]
Gene Ontology Molecular Function- actin binding [ISO]
- alpha-actinin binding [ISO]
- cell adhesion molecule binding [ISO]
- collagen binding [ISO]
- collagen binding involved in cell-matrix adhesion [ISO]
- fibronectin binding [ISO]
- glycoprotein binding [ISO]
- integrin binding [IPI, ISO]
- kinase binding [ISO]
- laminin binding [IDA, ISO]
- peptide binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- receptor binding [ISO]
- actin binding [ISO]
- alpha-actinin binding [ISO]
- cell adhesion molecule binding [ISO]
- collagen binding [ISO]
- collagen binding involved in cell-matrix adhesion [ISO]
- fibronectin binding [ISO]
- glycoprotein binding [ISO]
- integrin binding [IPI, ISO]
- kinase binding [ISO]
- laminin binding [IDA, ISO]
- peptide binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- receptor binding [ISO]
Gene Ontology Cellular Component
- acrosomal vesicle [ISO]
- adherens junction [ISO]
- basement membrane [ISO]
- cell surface [IDA, ISO]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- cytoplasmic vesicle [IDA]
- dendritic spine [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- filopodium [ISO]
- focal adhesion [ISO]
- hemidesmosome [ISO]
- integrin alpha1-beta1 complex [ISO]
- integrin alpha10-beta1 complex [ISO]
- integrin alpha11-beta1 complex [ISO]
- integrin alpha2-beta1 complex [ISO]
- integrin alpha3-beta1 complex [ISO]
- integrin alpha7-beta1 complex [IDA, IPI]
- integrin alpha9-beta1 complex [ISO]
- integrin complex [ISO]
- intercalated disc [IDA]
- invadopodium membrane [ISO]
- membrane [ISO]
- membrane raft [ISO]
- myelin sheath abaxonal region [IDA]
- neuromuscular junction [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
- ruffle membrane [ISO]
- sarcolemma [IDA, ISO]
- synapse [IDA]
- synaptic membrane [IDA]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.
Primary cilia are conserved sensory hubs essential for signaling transduction and embryonic development. Ciliary dysfunction causes a variety of developmental syndromes with neurological features and cognitive impairment, whose basis mostly remains unknown. Despite connections to neural function, the primary cilium remains an overlooked organelle in the brain. Most neurons have a primary cilium; however, it is still unclear how this ... [more]
bioRxiv Dec. 21, 2023; (); [Pubmed: 38187761]
Throughput
- High Throughput
Additional Notes
- BioID
- Proteins were considered hits if they showed at least a 2-fold enrichment in GPCRs-BirA2 compared to BirA alone, and a false discovery rate of at least 0.7 (p-value of 0.036 or lower)
Curated By
- BioGRID