BAIT
SSTR3
Smstr-3, Smstr3, sst3
somatostatin receptor 3
GO Process (9)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [IBA]
- behavior [IBA]
- cellular response to estradiol stimulus [IBA]
- cellular response to glucocorticoid stimulus [IBA]
- negative regulation of cell proliferation [IBA]
- neuropeptide signaling pathway [IBA]
- regulation of insulin secretion [IBA]
- somatostatin signaling pathway [IBA]
- synaptic transmission [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
STXBP1
AI317162, AI326233, MMS10-G, Ms10g, Munc-18a, Munc18-1, N-sec1, Rb-sec1, Sxtbp1, Unc18-1, Unc18h, nsec1, RP23-17P12.13-002
syntaxin binding protein 1
GO Process (16)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- axon target recognition [IMP]
- exocytosis [IMP]
- long term synaptic depression [IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of synaptic transmission, GABAergic [IDA]
- neuromuscular synaptic transmission [IMP]
- neurotransmitter secretion [IMP]
- platelet aggregation [ISO]
- platelet degranulation [ISO]
- positive regulation of calcium ion-dependent exocytosis [IDA]
- positive regulation of exocytosis [ISO]
- protein localization to plasma membrane [ISO]
- protein stabilization [ISO]
- regulation of synaptic vesicle priming [ISO]
- synaptic vesicle maturation [IMP]
- vesicle docking involved in exocytosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.
Primary cilia are conserved sensory hubs essential for signaling transduction and embryonic development. Ciliary dysfunction causes a variety of developmental syndromes with neurological features and cognitive impairment, whose basis mostly remains unknown. Despite connections to neural function, the primary cilium remains an overlooked organelle in the brain. Most neurons have a primary cilium; however, it is still unclear how this ... [more]
bioRxiv Dec. 21, 2023; (); [Pubmed: 38187761]
Throughput
- High Throughput
Additional Notes
- BioID
- Proteins were considered hits if they showed at least a 2-fold enrichment in GPCRs-BirA2 compared to BirA alone, and a false discovery rate of at least 0.7 (p-value of 0.036 or lower)
Curated By
- BioGRID