BAIT
SSTR3
Smstr-3, Smstr3, sst3
somatostatin receptor 3
GO Process (9)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [IBA]
- behavior [IBA]
- cellular response to estradiol stimulus [IBA]
- cellular response to glucocorticoid stimulus [IBA]
- negative regulation of cell proliferation [IBA]
- neuropeptide signaling pathway [IBA]
- regulation of insulin secretion [IBA]
- somatostatin signaling pathway [IBA]
- synaptic transmission [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
FYN
AI448320, AW552119
Fyn proto-oncogene
GO Process (29)
GO Function (17)
GO Component (10)
Gene Ontology Biological Process
- T cell receptor signaling pathway [IBA, ISO]
- activated T cell proliferation [IMP]
- cell surface receptor signaling pathway [IDA]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to platelet-derived growth factor stimulus [IDA]
- cellular response to transforming growth factor beta stimulus [IGI]
- dendrite morphogenesis [IMP]
- detection of mechanical stimulus involved in sensory perception of pain [IMP]
- forebrain development [IGI, IMP]
- innate immune response [IBA]
- myelination [TAS]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of protein catabolic process [IMP]
- neuron migration [IGI, IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI]
- positive regulation of neuron projection development [IGI]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein localization to nucleus [IDA]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [IMP]
- regulation of apoptotic process [IBA]
- regulation of cell proliferation [IBA]
- regulation of cell shape [IDA]
- response to ethanol [IGI]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function- CD4 receptor binding [ISO]
- CD8 receptor binding [ISO]
- G-protein coupled receptor binding [IPI]
- T cell receptor binding [ISO]
- ephrin receptor binding [ISO]
- glycoprotein binding [ISO]
- growth factor receptor binding [ISO]
- ion channel binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA, ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [ISO]
- tubulin binding [IDA]
- CD4 receptor binding [ISO]
- CD8 receptor binding [ISO]
- G-protein coupled receptor binding [IPI]
- T cell receptor binding [ISO]
- ephrin receptor binding [ISO]
- glycoprotein binding [ISO]
- growth factor receptor binding [ISO]
- ion channel binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA, ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [ISO]
- tubulin binding [IDA]
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.
Primary cilia are conserved sensory hubs essential for signaling transduction and embryonic development. Ciliary dysfunction causes a variety of developmental syndromes with neurological features and cognitive impairment, whose basis mostly remains unknown. Despite connections to neural function, the primary cilium remains an overlooked organelle in the brain. Most neurons have a primary cilium; however, it is still unclear how this ... [more]
bioRxiv Dec. 21, 2023; (); [Pubmed: 38187761]
Throughput
- High Throughput
Additional Notes
- BioID
- Proteins were considered hits if they showed at least a 2-fold enrichment in GPCRs-BirA2 compared to BirA alone, and a false discovery rate of at least 0.7 (p-value of 0.036 or lower)
Curated By
- BioGRID