BAIT
SSTR3
Smstr-3, Smstr3, sst3
somatostatin receptor 3
GO Process (9)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [IBA]
- behavior [IBA]
- cellular response to estradiol stimulus [IBA]
- cellular response to glucocorticoid stimulus [IBA]
- negative regulation of cell proliferation [IBA]
- neuropeptide signaling pathway [IBA]
- regulation of insulin secretion [IBA]
- somatostatin signaling pathway [IBA]
- synaptic transmission [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NLGN1
6330415N05Rik, BB179718, NL1, Nlg1, mKIAA1070
neuroligin 1
GO Process (38)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IDA, IMP, ISO]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA, ISO]
- cytoskeletal matrix organization at active zone [IMP, ISO]
- establishment of protein localization [IMP]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- nervous system development [IDA]
- neurexin clustering [IDA]
- neuron cell-cell adhesion [IDA, ISO]
- positive regulation of dendritic spine development [ISO]
- positive regulation of excitatory postsynaptic membrane potential [IDA, ISO]
- positive regulation of filopodium assembly [ISO]
- positive regulation of intracellular signal transduction [ISO]
- positive regulation of ruffle assembly [ISO]
- positive regulation of synapse assembly [IDA, ISO]
- positive regulation of synaptic transmission, GABAergic [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- positive regulation of synaptic vesicle endocytosis [IMP, ISO]
- positive regulation of synaptic vesicle exocytosis [IMP, ISO]
- postsynaptic density protein 95 clustering [IDA, ISO]
- postsynaptic membrane assembly [IDA]
- presynaptic membrane assembly [IDA, ISO]
- protein heterotetramerization [ISO]
- protein homooligomerization [IDA]
- protein localization to synapse [IDA]
- protein targeting [ISO]
- receptor localization to synapse [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IDA, ISO]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISO]
- regulation of inhibitory postsynaptic membrane potential [IMP]
- regulation of neuron differentiation [IDA]
- regulation of respiratory gaseous exchange by neurological system process [IGI]
- regulation of synaptic transmission [IGI]
- synapse assembly [IDA, ISO]
- synapse organization [IGI, ISO]
- synaptic vesicle clustering [IDA, ISO]
- synaptic vesicle targeting [IMP]
- terminal button organization [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.
Primary cilia are conserved sensory hubs essential for signaling transduction and embryonic development. Ciliary dysfunction causes a variety of developmental syndromes with neurological features and cognitive impairment, whose basis mostly remains unknown. Despite connections to neural function, the primary cilium remains an overlooked organelle in the brain. Most neurons have a primary cilium; however, it is still unclear how this ... [more]
bioRxiv Dec. 21, 2023; (); [Pubmed: 38187761]
Throughput
- High Throughput
Additional Notes
- BioID
- Proteins were considered hits if they showed at least a 2-fold enrichment in GPCRs-BirA2 compared to BirA alone, and a false discovery rate of at least 0.7 (p-value of 0.036 or lower)
Curated By
- BioGRID