BAIT
SSTR3
Smstr-3, Smstr3, sst3
somatostatin receptor 3
GO Process (9)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [IBA]
- behavior [IBA]
- cellular response to estradiol stimulus [IBA]
- cellular response to glucocorticoid stimulus [IBA]
- negative regulation of cell proliferation [IBA]
- neuropeptide signaling pathway [IBA]
- regulation of insulin secretion [IBA]
- somatostatin signaling pathway [IBA]
- synaptic transmission [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CDC42
AI747189, AU018915, RP23-246F18.2
cell division cycle 42
GO Process (50)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- GTP catabolic process [ISA]
- Golgi organization [ISO]
- Rho protein signal transduction [TAS]
- actin filament branching [ISO]
- actin filament bundle assembly [IMP]
- actin filament organization [ISO]
- adherens junction organization [IMP]
- canonical Wnt signaling pathway [IMP]
- cardiac conduction system development [IGI]
- cellular protein localization [IMP]
- dendritic cell migration [IGI]
- endosomal transport [TAS]
- epidermis morphogenesis [IMP]
- epithelial cell-cell adhesion [IMP]
- epithelial-mesenchymal cell signaling [IMP]
- establishment of Golgi localization [ISO]
- establishment or maintenance of apical/basal cell polarity [IMP]
- establishment or maintenance of cell polarity [TAS]
- filopodium assembly [IDA]
- hair follicle morphogenesis [IMP]
- hair follicle placode formation [IMP]
- heart contraction [IGI]
- keratinization [IMP]
- keratinocyte development [IMP]
- multicellular organism growth [IMP]
- negative regulation of gene expression [IMP]
- neuron fate determination [IMP]
- nuclear migration [IMP]
- nucleus localization [IMP]
- organelle transport along microtubule [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of MAPK cascade [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of hair follicle cell proliferation [IMP]
- positive regulation of intracellular protein transport [ISO]
- positive regulation of metalloenzyme activity [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of synapse structural plasticity [ISO]
- regulation of mitosis [IMP]
- regulation of protein catabolic process [IMP]
- regulation of protein heterodimerization activity [IDA]
- regulation of protein kinase activity [IMP]
- regulation of protein metabolic process [IMP]
- regulation of protein stability [IMP]
- single organismal cell-cell adhesion [IMP, TAS]
- sprouting angiogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.
Primary cilia are conserved sensory hubs essential for signaling transduction and embryonic development. Ciliary dysfunction causes a variety of developmental syndromes with neurological features and cognitive impairment, whose basis mostly remains unknown. Despite connections to neural function, the primary cilium remains an overlooked organelle in the brain. Most neurons have a primary cilium; however, it is still unclear how this ... [more]
bioRxiv Dec. 21, 2023; (); [Pubmed: 38187761]
Throughput
- High Throughput
Additional Notes
- BioID
- Proteins were considered hits if they showed at least a 2-fold enrichment in GPCRs-BirA2 compared to BirA alone, and a false discovery rate of at least 0.7 (p-value of 0.036 or lower)
Curated By
- BioGRID