USP13
Gene Ontology Biological Process
- cell proliferation [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein K63-linked deubiquitination [ISO]
- protein deubiquitination [IBA]
- protein stabilization [ISO]
- proteolysis [ISO]
- regulation of autophagy [IBA, ISO]
- regulation of proteasomal protein catabolic process [IBA]
- regulation of transcription, DNA-templated [ISO]
Gene Ontology Molecular Function
NFKBIA
Gene Ontology Biological Process
- cytoplasmic sequestering of NF-kappaB [ISO]
- cytoplasmic sequestering of transcription factor [ISO]
- lipopolysaccharide-mediated signaling pathway [IDA]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of Notch signaling pathway [IMP]
- negative regulation of lipid storage [ISO]
- negative regulation of macrophage derived foam cell differentiation [ISO]
- negative regulation of myeloid cell differentiation [IMP]
- nucleotide-binding oligomerization domain containing 1 signaling pathway [IDA]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [IDA]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cholesterol efflux [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IMP]
- protein import into nucleus, translocation [IDA]
- regulation of cell proliferation [IDA]
- regulation of gene expression [IMP]
- response to exogenous dsRNA [IDA]
- response to lipopolysaccharide [IDA]
- response to muramyl dipeptide [IDA]
- response to muscle stretch [IDA]
- toll-like receptor 4 signaling pathway [IDA]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Exosomal USP13 derived from microvascular endothelial cells regulates immune microenvironment and improves functional recovery after spinal cord injury by stabilizing I?B?.
Spinal cord injury (SCI) can result in irreversible sensory and motor disability with no effective treatment currently. After SCI, infiltrated macrophages accumulate in epicenter through destructed blood-spinal cord barrier (BSCB). Further, great majority of macrophages are preferentially polarized to M1 phenotype, with only a few transient M2 phenotype. The purpose of this study was to explore roles of vascular endothelial ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| USP13 NFKBIA | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| NFKBIA USP13 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID