NFE2L2
Gene Ontology Biological Process
- cellular response to fluid shear stress [ISO]
- cellular response to hydrogen peroxide [ISO]
- cellular response to laminar fluid shear stress [ISO]
- cellular response to oxidative stress [IDA, IMP]
- cellular response to tumor necrosis factor [ISO]
- endoplasmic reticulum unfolded protein response [IDA]
- negative regulation of cell death [ISO]
- negative regulation of endothelial cell apoptotic process [ISO]
- negative regulation of hydrogen peroxide-induced cell death [ISO]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- positive regulation of blood coagulation [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to stress [ISO]
- positive regulation of transcription, DNA-templated [IDA, IGI]
- proteasomal ubiquitin-independent protein catabolic process [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein ubiquitination [ISO]
- regulation of embryonic development [IGI]
- regulation of removal of superoxide radicals [IMP]
- regulation of transcription, DNA-templated [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription cofactor binding [ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription cofactor binding [ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
NEDD4
Gene Ontology Biological Process
- T cell activation [IMP]
- adaptive immune response [IMP]
- blood vessel morphogenesis [IGI, IMP]
- endocardial cushion development [IGI, IMP]
- negative regulation of sodium ion transport [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- neuromuscular junction development [IMP]
- outflow tract morphogenesis [IGI, IMP]
- positive regulation of protein catabolic process [IDA, ISO]
- protein K63-linked ubiquitination [ISO]
- protein monoubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, IMP]
- regulation of dendrite morphogenesis [IMP, ISO]
- regulation of synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke.
Stroke is the second leading cause of death worldwide, and oxidative stress plays a crucial role. Celastrol exhibits strong antioxidant properties in several diseases; however, whether it can affect oxidation in cerebral ischemic-reperfusion injury (CIRI) remains unclear. This study aimed to determine whether celastrol could reduce oxidative damage during CIRI and to elucidate the underlying mechanisms. Here, we found that ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID