SIK1
Gene Ontology Biological Process
- cardiac muscle cell differentiation [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- intracellular signal transduction [IDA, ISS]
- negative regulation of CREB transcription factor activity [ISS]
- negative regulation of gluconeogenesis [ISS]
- negative regulation of triglyceride biosynthetic process [ISS]
- positive regulation of anoikis [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA, ISS]
- regulation of cell differentiation [ISS]
- regulation of mitotic cell cycle [ISS]
- regulation of myotube differentiation [ISS]
- regulation of sodium ion transport [ISS]
Gene Ontology Molecular Function
HDAC5
Gene Ontology Biological Process
- B cell activation [TAS]
- B cell differentiation [TAS]
- Notch signaling pathway [TAS]
- cellular response to insulin stimulus [NAS]
- chromatin modification [TAS]
- chromatin organization [TAS]
- chromatin remodeling [TAS]
- chromatin silencing [TAS]
- histone deacetylation [IDA]
- inflammatory response [TAS]
- negative regulation of cell migration involved in sprouting angiogenesis [IMP]
- negative regulation of myotube differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [TAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of gene expression, epigenetic [IMP]
- regulation of myotube differentiation [ISS]
- regulation of protein binding [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
AKT Blocks SIK1-Mediated Repression of STAT3 to Promote Breast Tumorigenesis.
The PI3K-AKT signaling pathway is frequently dysregulated in cancer, and it is hyperactivated in approximately 50% of breast cancers. Although inhibitors directly targeting the PI3K-AKT axis have been developed, clinical efficacy has been limited to only a subset of patients. Identification of mechanisms underlying AKT-driven tumorigenesis could lead to alternative approaches to block pathway signaling and suppress breast tumor growth. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SIK1 HDAC5 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 836464 |
Curated By
- BioGRID