USP2
Gene Ontology Biological Process
- circadian behavior [ISS]
- circadian regulation of gene expression [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- locomotor rhythm [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of mitotic cell cycle [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA]
- protein stabilization [IDA, IMP]
- regulation of proteasomal protein catabolic process [IBA]
Gene Ontology Molecular Function
SLC2A1
Gene Ontology Biological Process
- L-ascorbic acid metabolic process [TAS]
- carbohydrate metabolic process [TAS]
- energy reserve metabolic process [TAS]
- glucose transport [IDA, TAS]
- hexose transport [TAS]
- protein complex assembly [IDA]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Deubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Lysosomal trafficking of the glucose transporter GLUT1 requires sequential regulation by TXNIP and ubiquitin.
Glucose transporters are gatekeepers of cellular glucose metabolism. Understanding how their activity is regulated can provide insight into mechanisms of glucose homeostasis and diseases arising from dysregulation of glucose transport. Glucose stimulates endocytosis of the human glucose transporter GLUT1, but several important questions remain surrounding the intracellular trafficking itinerary of GLUT1. Here, we report that increased glucose availability triggers lysosomal ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID