BAIT
B3GNT2
B3GN-T2, B3GNT, B3GNT-2, B3GNT1, BETA3GNT, BGNT2, BGnT-2
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
GO Process (9)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- O-glycan processing [TAS]
- carbohydrate metabolic process [TAS]
- cellular protein metabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- keratan sulfate biosynthetic process [TAS]
- keratan sulfate metabolic process [TAS]
- poly-N-acetyllactosamine biosynthetic process [IDA]
- post-translational protein modification [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC25A6
2, 3, AAC3, ANT, ANT 2, ANT 3, ANT3, ANT3Y, RP11-261P4.6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
GO Process (11)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- ADP transport [NAS]
- ATP transport [NAS]
- active induction of host immune response by virus [TAS]
- cellular protein metabolic process [TAS]
- energy reserve metabolic process [TAS]
- modulation by virus of host morphology or physiology [TAS]
- protein targeting to mitochondrion [TAS]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.
The cellular processes that govern tumor resistance to immunotherapy remain poorly understood. To gain insight into these processes, here we perform a genome-scale CRISPR activation screen for genes that enable human melanoma cells to evade cytotoxic T cell killing. Overexpression of four top candidate genes (CD274 (PD-L1), MCL1, JUNB, and B3GNT2) conferred resistance in diverse cancer cell types and mouse ... [more]
Nat Commun Mar. 25, 2022; 13(1);1606 [Pubmed: 35338135]
Throughput
- High Throughput
Curated By
- BioGRID