BAIT
RUNX2
AML3, Cbf, Cbfa-1, Cbfa1, LS3, Osf2, PEBP2aA, Pebp2a1, Pebpa2a
runt related transcription factor 2
GO Process (32)
GO Function (13)
GO Component (5)
Gene Ontology Biological Process
- BMP signaling pathway [IMP]
- T cell differentiation [IDA]
- cell maturation [IGI, IMP]
- cellular response to BMP stimulus [IMP]
- chondrocyte development [IMP]
- chondrocyte differentiation [IGI, IMP]
- embryonic cranial skeleton morphogenesis [IGI]
- embryonic forelimb morphogenesis [IMP]
- endochondral ossification [IMP]
- negative regulation of smoothened signaling pathway [IMP]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- odontogenesis of dentin-containing tooth [IMP]
- osteoblast development [IGI]
- osteoblast differentiation [IGI, IMP]
- osteoblast fate commitment [IGI]
- positive regulation of cell proliferation [IGI, IMP]
- positive regulation of chondrocyte differentiation [IMP]
- positive regulation of gene expression [IDA]
- positive regulation of ossification [ISO]
- positive regulation of osteoblast differentiation [IDA, IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [IMP]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of fibroblast growth factor receptor signaling pathway [IMP]
- regulation of odontogenesis of dentin-containing tooth [IMP]
- regulation of ossification [IMP]
- regulation of osteoblast differentiation [IDA]
- regulation of transcription, DNA-templated [TAS]
- skeletal system development [IMP]
- skeletal system morphogenesis [IMP]
- stem cell differentiation [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- bHLH transcription factor binding [IPI]
- chromatin binding [IDA]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA, IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- bHLH transcription factor binding [IPI]
- chromatin binding [IDA]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
SHC1
Shc, ShcA, p66, p66shc
src homology 2 domain-containing transforming protein C1
GO Process (16)
GO Function (12)
GO Component (5)
Gene Ontology Biological Process
- MAPK cascade [ISO]
- actin cytoskeleton organization [ISO]
- actin cytoskeleton reorganization [IMP]
- activation of MAPK activity [IMP, ISO]
- aging [ISO]
- angiogenesis [IMP]
- epidermal growth factor receptor signaling pathway [IBA, IDA]
- heart development [IMP]
- insulin receptor signaling pathway [IBA, ISO]
- neuron differentiation [ISO]
- neuron projection development [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of vasoconstriction [ISO]
- regulation of cell proliferation [IMP]
- single organismal cell-cell adhesion [IMP]
Gene Ontology Molecular Function- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- insulin receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IBA]
- protein phosphatase 2A binding [ISO]
- receptor tyrosine kinase binding [IPI, ISO]
- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- insulin receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IBA]
- protein phosphatase 2A binding [ISO]
- receptor tyrosine kinase binding [IPI, ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration.
Matrix metallopeptidases (MMPs) are critical matrix-degrading molecules and they are frequently overexpressed in degenerative discs. This study aimed to investigate the mechanism for MMP upregulation.Immunoblot and RT-qPCR were used for detecting protein and gene expression levels. 4-month-old and 24-month-old C57BL/6 mice were used for evaluating intervertebral disc degeneration (IDD). An ubiquitination assay was used to determine protein modification. Immunoprecipitation and ... [more]
Life Sci May. 01, 2023; 320();121555 [Pubmed: 36878279]
Throughput
- Low Throughput
Curated By
- BioGRID