BAIT
RUNX2
AML3, Cbf, Cbfa-1, Cbfa1, LS3, Osf2, PEBP2aA, Pebp2a1, Pebpa2a
runt related transcription factor 2
GO Process (32)
GO Function (13)
GO Component (5)
Gene Ontology Biological Process
- BMP signaling pathway [IMP]
- T cell differentiation [IDA]
- cell maturation [IGI, IMP]
- cellular response to BMP stimulus [IMP]
- chondrocyte development [IMP]
- chondrocyte differentiation [IGI, IMP]
- embryonic cranial skeleton morphogenesis [IGI]
- embryonic forelimb morphogenesis [IMP]
- endochondral ossification [IMP]
- negative regulation of smoothened signaling pathway [IMP]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- odontogenesis of dentin-containing tooth [IMP]
- osteoblast development [IGI]
- osteoblast differentiation [IGI, IMP]
- osteoblast fate commitment [IGI]
- positive regulation of cell proliferation [IGI, IMP]
- positive regulation of chondrocyte differentiation [IMP]
- positive regulation of gene expression [IDA]
- positive regulation of ossification [ISO]
- positive regulation of osteoblast differentiation [IDA, IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [IMP]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of fibroblast growth factor receptor signaling pathway [IMP]
- regulation of odontogenesis of dentin-containing tooth [IMP]
- regulation of ossification [IMP]
- regulation of osteoblast differentiation [IDA]
- regulation of transcription, DNA-templated [TAS]
- skeletal system development [IMP]
- skeletal system morphogenesis [IMP]
- stem cell differentiation [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- bHLH transcription factor binding [IPI]
- chromatin binding [IDA]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA, IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- bHLH transcription factor binding [IPI]
- chromatin binding [IDA]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
PDPK1
Pdk1, RP23-153H18.1
3-phosphoinositide dependent protein kinase 1
GO Process (23)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- activation of protein kinase B activity [ISO]
- calcium-mediated signaling [ISO]
- cell migration [ISO]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to insulin stimulus [ISO]
- epidermal growth factor receptor signaling pathway [ISO]
- extrinsic apoptotic signaling pathway [ISO]
- focal adhesion assembly [ISO]
- hyperosmotic response [IDA]
- negative regulation of cardiac muscle cell apoptotic process [IMP]
- negative regulation of protein kinase activity [ISO]
- negative regulation of toll-like receptor signaling pathway [IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of phospholipase activity [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- regulation of endothelial cell migration [IMP]
- regulation of mast cell degranulation [IMP]
- signal transduction [TAS]
- type B pancreatic cell development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration.
Matrix metallopeptidases (MMPs) are critical matrix-degrading molecules and they are frequently overexpressed in degenerative discs. This study aimed to investigate the mechanism for MMP upregulation.Immunoblot and RT-qPCR were used for detecting protein and gene expression levels. 4-month-old and 24-month-old C57BL/6 mice were used for evaluating intervertebral disc degeneration (IDD). An ubiquitination assay was used to determine protein modification. Immunoprecipitation and ... [more]
Life Sci May. 01, 2023; 320();121555 [Pubmed: 36878279]
Throughput
- Low Throughput
Curated By
- BioGRID