Publication

Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly.

Schaan Profes M, Tiroumalechetty A, Patel N, Lauar SS, Sidoli S, Kurshan PT

Neurexins are highly spliced transmembrane cell adhesion molecules that bind an array of partners via their extracellular domains. However, much less is known about the signaling pathways downstream of neurexin's largely invariant intracellular domain (ICD). Caenorhabditis elegans contains a single neurexin gene that we have previously shown is required for presynaptic assembly and stabilization. To gain insight into the signaling ... [more]

Throughput

• High Throughput

Additional Notes

• BioID
• High confidence hits were identified relative to the specific endogenous control strain (neurexin-deltaPBM-TurboID) which differs only in its subcellular neurexin localization pattern (loss of synaptic enrichment).
• TurboID proximity labeling method to identify protein interactors of neurexin's (NRX-1) intracellular domain.

Curated By

• BioGRID