BAIT

ANKRD35

ankyrin repeat domain 35
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

CACYBP

GIG5, S100A6BP, SIP, PNAS-107
calcyclin binding protein
UPS Project
GO Process (0)
GO Function (2)
GO Component (4)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

The E3 ligase RBCK1 reduces the sensitivity of ccRCC to sunitinib through the ANKRD35-MITD1-ANXA1 axis.

Wang Y, Peng M, Zhong Y, Xiong W, Zhu L, Jin X

Despite the promise of targeted tyrosine kinase inhibitors (TKIs), such as sunitinib, in the extension of survival time in patients with clear cell renal cell carcinoma (ccRCC) progression or metastasis, the patients eventually succumb to inevitable drug resistance. Protein degradation executed by the ubiquitin-dependent proteasome system played an important role in determining the sensitivity of ccRCC to sunitinib. Here, we ... [more]

Oncogene Mar. 01, 2023; 42(13);952-966 [Pubmed: 36732658]

Throughput

  • High Throughput

Curated By

  • BioGRID