BAIT
CEMIP
CCSP1, KIAA1199, TMEM2L
cell migration inducing protein, hyaluronan binding
GO Process (7)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- hyaluronan catabolic process [IMP]
- positive regulation of cell migration [IDA]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- positive regulation of protein kinase C activity [IDA]
- positive regulation of protein targeting to membrane [IDA]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PPP2CA
PP2Ac, PP2CA, PP2Calpha, RP-C
protein phosphatase 2, catalytic subunit, alpha isozyme
GO Process (24)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- RNA splicing [NAS]
- apoptotic process [TAS]
- ceramide metabolic process [NAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- inactivation of MAPK activity [NAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope reassembly [TAS]
- negative regulation of cell growth [NAS]
- negative regulation of epithelial to mesenchymal transition [IMP]
- negative regulation of tyrosine phosphorylation of Stat3 protein [NAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- positive regulation of protein serine/threonine kinase activity [IMP]
- protein dephosphorylation [TAS]
- regulation of DNA replication [NAS]
- regulation of Wnt signaling pathway [NAS]
- regulation of cell adhesion [NAS]
- regulation of cell differentiation [NAS]
- regulation of growth [NAS]
- regulation of transcription, DNA-templated [NAS]
- response to organic substance [NAS]
- second-messenger-mediated signaling [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway.
Metastasis is the leading cause of treatment failure and tumor-related death in colorectal cancer (CRC). Our previous studies report that CEMIP functionally promotes CRC metastasis and is closely related to poor outcomes. However, the molecular network of CEMIP promoting CRC metastasis is still not fully understood. In the current study, we identify CEMIP interacting with GRAF1, and the combination of ... [more]
Cell Death Dis Feb. 27, 2023; 14(2);167 [Pubmed: 36849460]
Throughput
- Low Throughput
Curated By
- BioGRID