BAIT
USP25
ubiquitin specific peptidase 25
GO Process (7)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein K48-linked deubiquitination [ISO]
- protein K63-linked deubiquitination [ISO]
- protein deubiquitination [IBA]
- proteolysis [ISO]
- regulation of proteasomal protein catabolic process [IBA]
- ubiquitin-dependent protein catabolic process [ISS]
Gene Ontology Molecular Function
Mus musculus
PREY
SLC25A5
Ant2, RP23-286I5.1
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5
GO Process (2)
GO Function (1)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP25 deficiency promotes T cell dysfunction and transplant acceptance via mitochondrial dynamics.
During organ transplantation, pharmacologic drugs targeting T cell activation signal to inhibit T cell-mediated allo-rejection are insufficient and not durable to suppress chronic rejection. Recent advances highlight an exhausted or dysfunctional status of T cells, which favor transplant acceptance.The models of MHC-mismatched (BALB/c to C57BL/6 or USP25 KO mice) heterotopic heart transplantation and skin transplantation were utilized to evaluate the ... [more]
Int Immunopharmacol Apr. 01, 2023; 117();109917 [Pubmed: 36822087]
Throughput
- Low Throughput
Curated By
- BioGRID