BAIT
USP25
ubiquitin specific peptidase 25
GO Process (7)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein K48-linked deubiquitination [ISO]
- protein K63-linked deubiquitination [ISO]
- protein deubiquitination [IBA]
- proteolysis [ISO]
- regulation of proteasomal protein catabolic process [IBA]
- ubiquitin-dependent protein catabolic process [ISS]
Gene Ontology Molecular Function
Mus musculus
PREY
RPS6
S6R
ribosomal protein S6
GO Process (16)
GO Function (4)
GO Component (13)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- T cell differentiation in thymus [IGI, IMP]
- T cell proliferation involved in immune response [IGI, IMP]
- TOR signaling [ISO]
- activation-induced cell death of T cells [IMP]
- erythrocyte development [IMP]
- gastrulation [IGI, IMP]
- glucose homeostasis [IDA]
- mitotic cell cycle checkpoint [IMP]
- mitotic nuclear division [IMP]
- negative regulation of apoptotic process [IMP]
- oogenesis stage [IMP]
- placenta development [IMP]
- positive regulation of apoptotic process [ISO]
- rRNA processing [IMP, ISO]
- ribosomal small subunit biogenesis [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell body [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic ribonucleoprotein granule [ISO]
- cytosolic small ribosomal subunit [IBA, IDA, ISO]
- dendrite [IDA, ISO]
- membrane [ISO]
- nucleolus [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- polysome [IDA]
- ribonucleoprotein complex [ISO]
- ribosome [IDA]
- small ribosomal subunit [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP25 deficiency promotes T cell dysfunction and transplant acceptance via mitochondrial dynamics.
During organ transplantation, pharmacologic drugs targeting T cell activation signal to inhibit T cell-mediated allo-rejection are insufficient and not durable to suppress chronic rejection. Recent advances highlight an exhausted or dysfunctional status of T cells, which favor transplant acceptance.The models of MHC-mismatched (BALB/c to C57BL/6 or USP25 KO mice) heterotopic heart transplantation and skin transplantation were utilized to evaluate the ... [more]
Int Immunopharmacol Apr. 01, 2023; 117();109917 [Pubmed: 36822087]
Throughput
- Low Throughput
Curated By
- BioGRID