RNF138
Gene Ontology Molecular Function
ARID1A
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IDA]
- androgen receptor signaling pathway [ISO]
- cardiac chamber development [IMP]
- cardiac muscle cell differentiation [IMP]
- chromatin organization [IPI]
- chromatin remodeling [ISO]
- forebrain development [IMP]
- glucocorticoid receptor signaling pathway [ISO]
- intracellular estrogen receptor signaling pathway [ISO]
- maintenance of chromatin silencing [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- neural tube closure [IMP]
- nucleosome disassembly [ISO]
- optic cup formation involved in camera-type eye development [IMP]
- placenta blood vessel development [IMP]
- positive regulation of transcription, DNA-templated [ISO]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.
As one of the core components of the switching or sucrose non-fermentable (SWI/SNF) complex, SMARCC1 (BAF155, SRG3) plays essential roles in activation of late inflammatory genes in response to microbial challenge. However, little is known about the mechanism of how SMARCC1 regulates the inflammatory innate response. Via functional screening, we identify the nuclear E3 ubiquitin ligase RNF138 as a negative ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RNF138 ARID1A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 3651591 |
Curated By
- BioGRID