BAIT
RNF138
2410015A17Rik, 2810480D20Rik, STRIN, Trif, Trif-d
ring finger protein 138
GO Process (0)
GO Function (1)
GO Component (1)
Gene Ontology Molecular Function
Mus musculus
PREY
UPF1
B430202H16Rik, NORF1, PNORF-1, Rent1, Upflp
UPF1 regulator of nonsense transcripts homolog (yeast)
GO Process (8)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- DNA repair [ISO]
- DNA replication [ISO]
- dosage compensation by inactivation of X chromosome [IMP]
- histone mRNA catabolic process [ISO]
- nuclear-transcribed mRNA catabolic process [ISO]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [ISO]
- regulation of translational termination [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.
As one of the core components of the switching or sucrose non-fermentable (SWI/SNF) complex, SMARCC1 (BAF155, SRG3) plays essential roles in activation of late inflammatory genes in response to microbial challenge. However, little is known about the mechanism of how SMARCC1 regulates the inflammatory innate response. Via functional screening, we identify the nuclear E3 ubiquitin ligase RNF138 as a negative ... [more]
Cell Rep Feb. 28, 2023; 42(2);112097 [Pubmed: 36800290]
Throughput
- High Throughput
Curated By
- BioGRID