BAIT

RNF138

2410015A17Rik, 2810480D20Rik, STRIN, Trif, Trif-d

ring finger protein 138

GO Process (0)

GO Function (1)

GO Component (1)

Gene Ontology Molecular Function

protein kinase binding [ISO]

Gene Ontology Cellular Component

CRISPR Database MGI Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

PREY

CAD

2410008J01Rik, AU018859, Cpad

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

GO Process (7)

GO Function (10)

GO Component (12)

Gene Ontology Biological Process

'de novo' pyrimidine nucleobase biosynthetic process [IBA, ISO]

UTP biosynthetic process [ISO]

arginine biosynthetic process [IBA]

drug metabolic process [ISO]

peptidyl-threonine phosphorylation [ISO]

protein autophosphorylation [ISO]

urea cycle [IBA]

Gene Ontology Molecular Function

ATP binding [ISO]
UTP binding [ISO]
aspartate carbamoyltransferase activity [IBA, ISO]
carbamoyl-phosphate synthase (ammonia) activity [IBA]
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [IBA, ISO]
dihydroorotase activity [IBA, ISO]
enzyme binding [ISO]
identical protein binding [ISO]
protein kinase activity [ISO]
zinc ion binding [ISO]

Gene Ontology Cellular Component

cell projection [ISO]

cytoplasm [IBA, ISO]

extracellular vesicular exosome [ISO]

neuronal cell body [ISO]

nuclear matrix [ISO]

nucleoplasm [ISO]

plasma membrane [ISO]

protein complex [ISO]

terminal bouton [ISO]

CRISPR Database MGI Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.

Liu W, Wang Z, Liu S, Zhang X, Cao X, Jiang M

As one of the core components of the switching or sucrose non-fermentable (SWI/SNF) complex, SMARCC1 (BAF155, SRG3) plays essential roles in activation of late inflammatory genes in response to microbial challenge. However, little is known about the mechanism of how SMARCC1 regulates the inflammatory innate response. Via functional screening, we identify the nuclear E3 ubiquitin ligase RNF138 as a negative ... [more]

Cell Rep Feb. 28, 2023; 42(2);112097 [Pubmed: 36800290]

Throughput

High Throughput

Curated By

BioGRID