RNF138
Gene Ontology Molecular Function
SMARCC2
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [ISO]
- chromatin remodeling [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- negative regulation of transcription, DNA-templated [ISO]
- nucleosome disassembly [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.
As one of the core components of the switching or sucrose non-fermentable (SWI/SNF) complex, SMARCC1 (BAF155, SRG3) plays essential roles in activation of late inflammatory genes in response to microbial challenge. However, little is known about the mechanism of how SMARCC1 regulates the inflammatory innate response. Via functional screening, we identify the nuclear E3 ubiquitin ligase RNF138 as a negative ... [more]
Throughput
- Low Throughput
Additional Notes
- Interaction dependent on SMARCC1
Curated By
- BioGRID