GABARAP
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TNIP1
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [ISS]
- defense response [TAS]
- glycoprotein biosynthetic process [IDA]
- leukocyte cell-cell adhesion [IMP]
- modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of viral genome replication [TAS]
- positive regulation of inflammatory response [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- translation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.
Limitation of excessive inflammation due to selective degradation of pro-inflammatory proteins is one of the cytoprotective functions attributed to autophagy. In the current study, we highlight that selective autophagy also plays a vital role in promoting the establishment of a robust inflammatory response. Under inflammatory conditions, here TLR3-activation by poly(I:C) treatment, the inflammation repressor TNIP1 (TNFAIP3 interacting protein 1) is ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID