BAIT
TNIP1
ABIN-1, NAF1, VAN, nip40-1
TNFAIP3 interacting protein 1
GO Process (11)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [ISS]
- defense response [TAS]
- glycoprotein biosynthetic process [IDA]
- leukocyte cell-cell adhesion [IMP]
- modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of viral genome replication [TAS]
- positive regulation of inflammatory response [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- translation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PRMT5
HRMT1L5, IBP72, JBP1, SKB1, SKB1Hs
protein arginine methyltransferase 5
GO Process (13)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- cell proliferation [TAS]
- circadian regulation of gene expression [ISS]
- endothelial cell activation [IMP]
- gene expression [TAS]
- histone H4-R3 methylation [ISS, NAS]
- ncRNA metabolic process [TAS]
- peptidyl-arginine N-methylation [IDA]
- peptidyl-arginine methylation [IMP]
- peptidyl-arginine methylation, to symmetrical-dimethyl arginine [IMP]
- regulation of mitosis [TAS]
- regulation of transcription, DNA-templated [IBA]
- spliceosomal snRNP assembly [IMP, TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.
Limitation of excessive inflammation due to selective degradation of pro-inflammatory proteins is one of the cytoprotective functions attributed to autophagy. In the current study, we highlight that selective autophagy also plays a vital role in promoting the establishment of a robust inflammatory response. Under inflammatory conditions, here TLR3-activation by poly(I:C) treatment, the inflammation repressor TNIP1 (TNFAIP3 interacting protein 1) is ... [more]
J Cell Biol Feb. 06, 2023; 222(2); [Pubmed: 36574265]
Throughput
- Low Throughput
Curated By
- BioGRID