BAIT
YAP1
COB1, YAP, YAP2, YAP65, YKI
Yes-associated protein 1
GO Process (8)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- cell proliferation [IDA]
- cellular response to DNA damage stimulus [IDA]
- cellular response to gamma radiation [IDA]
- contact inhibition [IDA]
- gene expression [TAS]
- hippo signaling [TAS]
- negative regulation of nucleic acid-templated transcription [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
VCL
CMD1W, CMH15, HEL114, MV, MVCL, RP11-178G16.3
vinculin
GO Process (15)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- adherens junction assembly [IMP]
- apical junction assembly [IMP]
- blood coagulation [TAS]
- cell adhesion [TAS]
- cell-matrix adhesion [TAS]
- cellular component movement [TAS]
- epithelial cell-cell adhesion [IMP]
- lamellipodium assembly [ISS]
- morphogenesis of an epithelium [IMP]
- muscle contraction [TAS]
- negative regulation of cell migration [TAS]
- platelet activation [TAS]
- platelet aggregation [IMP]
- platelet degranulation [TAS]
- protein localization to cell surface [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.
The activation of YAP/TAZ, a pair of paralogs of transcriptional coactivators, initiates a dysregulated transcription program, which is a key feature of human cancer cells. However, it is not fully understood how YAP/TAZ promote dysregulated transcription for tumor progression. In this study, we employed the BioID method to identify the interactome of YAP/TAZ and discovered that YAP/TAZ interact with multiple ... [more]
Cancer Lett Jan. 26, 2024; 585();216667 [Pubmed: 38280479]
Throughput
- High Throughput
Additional Notes
- BioID
- Interaction is part of the YAP interactome in total cells
Curated By
- BioGRID