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BAIT

CFTR

ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1, tcag7.78

cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

GO Process (9)

GO Function (9)

GO Component (10)

Gene Ontology Biological Process

cellular response to cAMP [ISS]

chloride transmembrane transport [IDA, ISS, NAS, TAS]

intracellular pH elevation [ISS]

membrane hyperpolarization [ISS]

positive regulation of voltage-gated chloride channel activity [IDA]

respiratory gaseous exchange [TAS]

sperm capacitation [ISS]

transmembrane transport [TAS]

transport [TAS]

Gene Ontology Molecular Function

ATP-binding and phosphorylation-dependent chloride channel activity [TAS]
PDZ domain binding [IDA]
bicarbonate transmembrane transporter activity [ISS]
channel-conductance-controlling ATPase activity [NAS]
chloride channel activity [IDA]
chloride channel inhibitor activity [IDA]
chloride transmembrane transporter activity [ISS]
enzyme binding [IPI]
protein binding [IPI]

Gene Ontology Cellular Component

apical plasma membrane [IDA]

basolateral plasma membrane [NAS]

cell surface [IDA]

cytoplasm [IDA]

early endosome [IDA]

endoplasmic reticulum Sec complex [IDA]

extracellular vesicular exosome [IDA]

plasma membrane [IDA, TAS]

protein complex [IDA]

recycling endosome [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

ESYT2

CHR2SYT, E-Syt2, FAM62B, tcag7.562

extended synaptotagmin-like protein 2

GO Process (0)

GO Function (7)

GO Component (5)

Gene Ontology Molecular Function

calcium ion binding [IDA]
calcium-dependent phospholipid binding [IDA]
identical protein binding [IPI]
phosphatidylcholine binding [IDA]
phosphatidylethanolamine binding [IDA]
phosphatidylinositol binding [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

extrinsic component of cytoplasmic side of plasma membrane [IMP]

integral component of plasma membrane [IDA]

intrinsic component of endoplasmic reticulum membrane [IDA]

organelle membrane contact site [IDA]

CRISPR Database VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.

Matos AM, Pinto FR, Barros P, Amaral MD, Pepperkok R, Matos P

Cystic fibrosis (CF) is a genetic disease caused by mutations in the gene encoding CF transmembrane conductance regulator (CFTR), a chloride channel normally expressed at the surface of epithelial cells. The most frequent mutation, resulting in Phe-508 deletion, causes CFTR misfolding and its premature degradation. Low temperature or pharmacological correctors can partly rescue the Phe508del-CFTR processing defect and enhance trafficking ... [more]

J Biol Chem Sep. 06, 2019; 294(36);13396-13410 [Pubmed: 31324722]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CFTR ESYT2	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Pankow S (2015)	High	-	BioGRID	2448218

Curated By

BioGRID