TIMP1
Gene Ontology Biological Process
- blood coagulation [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of membrane protein ectodomain proteolysis [IDA]
- negative regulation of metalloenzyme activity [IDA]
- negative regulation of trophoblast cell migration [IMP]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of cell proliferation [IDA]
- regulation of integrin-mediated signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MMP9
Gene Ontology Biological Process
- collagen catabolic process [TAS]
- endodermal cell differentiation [IEP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- macrophage differentiation [TAS]
- negative regulation of cation channel activity [IDA]
- positive regulation of keratinocyte migration [IMP]
- positive regulation of receptor binding [IDA]
- proteolysis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Matrix metalloproteinases in human gliomas: activation of matrix metalloproteinase-2 (MMP-2) may be correlated with membrane-type-1 matrix metalloproteinase (MT1-MMP) expression.
To evaluate possible roles of matrix metalloproteinase (MMP)-1, -2, tissue inhibitor of metalloproteinase (TIMP)-1, -2 and membrane-type-1 matrix metalloproteinase (MT1-MMP) in invasion of human gliomas, expressions of these proteins were investigated in ten cases of human glioma and two meningioma tissues and eight human glioma cell lines. In gelatin zymography, MMP-2 activities of glioblastomas were higher than astrocytomas. The activated ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MMP9 TIMP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2220374 | |
| MMP9 TIMP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3252625 | |
| MMP9 TIMP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3099301 |
Curated By
- BioGRID