RAF1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [IDA, TAS]
- activation of adenylate cyclase activity [NAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell proliferation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- ion transmembrane transport [TAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- negative regulation of protein complex assembly [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- regulation of Rho protein signal transduction [TAS]
- regulation of apoptotic process [TAS]
- regulation of cell differentiation [TAS]
- regulation of cell motility [TAS]
- signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- synaptic transmission [TAS]
- transmembrane transport [TAS]
- wound healing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ATP2B4
Gene Ontology Biological Process
- blood coagulation [TAS]
- calcium ion homeostasis [IC]
- calcium ion import across plasma membrane [IC]
- calcium ion transmembrane transport [IMP]
- cellular calcium ion homeostasis [IDA]
- cellular response to epinephrine stimulus [IDA]
- ion transmembrane transport [TAS]
- negative regulation of adrenergic receptor signaling pathway involved in heart process [IDA]
- negative regulation of arginine catabolic process [IDA]
- negative regulation of calcineurin-NFAT signaling cascade [IDA]
- negative regulation of cardiac muscle hypertrophy in response to stress [IMP]
- negative regulation of citrulline biosynthetic process [IDA]
- negative regulation of nitric oxide biosynthetic process [IDA]
- negative regulation of nitric oxide mediated signal transduction [IDA]
- negative regulation of nitric-oxide synthase activity [IDA]
- negative regulation of peptidyl-cysteine S-nitrosylation [NAS]
- negative regulation of the force of heart contraction [IDA]
- positive regulation of cAMP-dependent protein kinase activity [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- regulation of sodium ion transmembrane transport [IC]
- regulation of transcription from RNA polymerase II promoter [IMP]
- response to hydrostatic pressure [IMP]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Mitochondrial Raf1 Regulates Glutamine Catabolism.
Raf1 is present within the mitochondrial matrix, where it binds GLS to regulate glutamine catabolism and tumorigenesis. In cancer, Raf1 activation occurs via mechanisms that include mutation of upstream regulators, such as receptor tyrosine kinases and Ras GTPases, as well as by mutations that affect RAF1 itself, including via gene amplification ( 1 - 4 ). Once recruited to the ... [more]
Throughput
- High Throughput
Additional Notes
- BioID
- Raf1 proximal protein with SAINT greater or equal to 0.9 in melanoma cell lines
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAF1 ATP2B4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID