RAF1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [IDA, TAS]
- activation of adenylate cyclase activity [NAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell proliferation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- ion transmembrane transport [TAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- negative regulation of protein complex assembly [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- regulation of Rho protein signal transduction [TAS]
- regulation of apoptotic process [TAS]
- regulation of cell differentiation [TAS]
- regulation of cell motility [TAS]
- signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- synaptic transmission [TAS]
- transmembrane transport [TAS]
- wound healing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PKP2
Gene Ontology Biological Process
- adherens junction maintenance [ISS]
- bundle of His cell to Purkinje myocyte communication [IMP]
- cardiac muscle cell action potential [ISS]
- cardiac muscle cell action potential involved in contraction [IMP]
- cell communication by electrical coupling involved in cardiac conduction [ISS]
- cell-cell signaling involved in cardiac conduction [IMP]
- desmosome assembly [IMP]
- gap junction assembly [ISS]
- heart development [ISS]
- intermediate filament bundle assembly [IMP]
- lipid homeostasis [ISS]
- maintenance of organ identity [IMP]
- negative regulation of cell migration [ISS]
- negative regulation of cell proliferation [ISS]
- positive regulation of sodium ion transport [ISS]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of tight junction assembly [ISS]
- single organismal cell-cell adhesion [ISS, NAS]
- ventricular cardiac muscle cell action potential [IMP]
- ventricular cardiac muscle tissue morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Mitochondrial Raf1 Regulates Glutamine Catabolism.
Raf1 is present within the mitochondrial matrix, where it binds GLS to regulate glutamine catabolism and tumorigenesis. In cancer, Raf1 activation occurs via mechanisms that include mutation of upstream regulators, such as receptor tyrosine kinases and Ras GTPases, as well as by mutations that affect RAF1 itself, including via gene amplification ( 1 - 4 ). Once recruited to the ... [more]
Throughput
- High Throughput
Additional Notes
- BioID
- Raf1 proximal protein with SAINT greater or equal to 0.9 in pancreatic cell lines
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAF1 PKP2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID