FOXP4
Gene Ontology Molecular Function
NR2F2
Gene Ontology Biological Process
- intracellular receptor signaling pathway [IDA, TAS]
- lipid metabolic process [TAS]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- negative regulation of endothelial cell migration [IMP]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of transcription involved in lymphatic endothelial cell fate commitment [IMP]
- signal transduction [TAS]
Gene Ontology Molecular Function- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- retinoic acid binding [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IC, IDA]
- transcription corepressor activity [TAS]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- retinoic acid binding [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IC, IDA]
- transcription corepressor activity [TAS]
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders.
FOXP transcription factors play important roles in neurodevelopment, but little is known about how their transcriptional activity is regulated. FOXP proteins cooperatively regulate gene expression by forming homo- and hetero-dimers with each other. Physical associations with other transcription factors might also modulate the functions of FOXP proteins. However, few FOXP-interacting transcription factors have been identified so far. Therefore, we sought ... [more]
Throughput
- Low Throughput
Additional Notes
- BRET
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FOXP4 NR2F2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID