TNFSF11
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IDA]
- TNFSF11-mediated signaling pathway [ISO]
- activation of JUN kinase activity [IDA]
- bone resorption [IDA]
- calcium ion homeostasis [IGI]
- cytokine-mediated signaling pathway [ISO]
- lymph node development [TAS]
- mammary gland alveolus development [IMP]
- mammary gland epithelial cell proliferation [IMP]
- monocyte chemotaxis [ISO]
- organ morphogenesis [IMP]
- ossification [IMP]
- osteoclast differentiation [IDA, IGI, IMP, ISO]
- osteoclast proliferation [IDA]
- positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IGI]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of T cell activation [ISO]
- positive regulation of bone resorption [ISO]
- positive regulation of corticotropin-releasing hormone secretion [IDA]
- positive regulation of fever generation by positive regulation of prostaglandin secretion [IDA]
- positive regulation of homotypic cell-cell adhesion [ISO]
- positive regulation of intracellular signal transduction [ISO]
- positive regulation of osteoclast development [IDA]
- positive regulation of osteoclast differentiation [IDA, IGI, ISO]
- positive regulation of phosphorylation [IDA]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein homooligomerization [IDA]
- regulation of osteoclast differentiation [IDA]
- tumor necrosis factor-mediated signaling pathway [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
STAC2
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The histone methyltransferase ASH1L protects against bone loss by inhibiting osteoclastogenesis.
Absent, small, or homeotic1-like (ASH1L) is a histone lysine methyltransferase that generally functions as a transcriptional activator in controlling cell fate. So far, its physiological relevance in bone homeostasis and osteoclast differentiation remains elusive. Here, by?conditional?deleting Ash1l in osteoclast progenitors of mice, we found ASH1L deficiency resulted in osteoporosis and potentiation of osteoclastogenesis in vivo and in vitro. Mechanistically, ASH1L ... [more]
Throughput
- Low Throughput
Additional Notes
- ChIP
Curated By
- BioGRID