Translational control of mRNAs allows for rapid and selective changes in synaptic protein expression that are required for long-lasting plasticity and memory formation in the brain. Fragile X Related Protein 1 (FXR1P) is an RNA-binding protein that controls mRNA translation in nonneuronal cells and colocalizes with translational machinery in neurons. However, its neuronal mRNA targets and role in the brain ... [more]

Cell Rep Nov. 20, 2014; 9(4);1402-1416 [Pubmed: 25456134]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

FXR1

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA binding [TAS]mRNA binding [IBA]poly(A) RNA binding [IDA]

Gene Ontology Cellular Component

GRIA2

Gene Ontology Biological Process

Gene Ontology Molecular Function

alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISS]extracellular-glutamate-gated ion channel activity [IBA]ionotropic glutamate receptor activity [IDA]protein binding [IPI]

Gene Ontology Cellular Component

Protein-RNA

Publication

FXR1P limits long-term memory, long-lasting synaptic potentiation, and de novo GluA2 translation.

Throughput

Curated By

RNA binding [TAS]
mRNA binding [IBA]
poly(A) RNA binding [IDA]

alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISS]
extracellular-glutamate-gated ion channel activity [IBA]
ionotropic glutamate receptor activity [IDA]
protein binding [IPI]