BAIT
CTNNB1
Bfc, Catnb, Mesc
catenin (cadherin associated protein), beta 1
GO Process (137)
GO Function (14)
GO Component (29)
Gene Ontology Biological Process
- T cell differentiation [IMP]
- T cell differentiation in thymus [IMP]
- Wnt signaling pathway [IDA]
- adherens junction organization [IMP]
- anterior/posterior axis specification [IMP]
- bone resorption [IGI, IMP]
- branching involved in ureteric bud morphogenesis [IMP]
- canonical Wnt signaling pathway [IDA, IGI, IMP]
- canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [IMP]
- cardiac muscle cell proliferation [TAS]
- cardiac vascular smooth muscle cell differentiation [TAS]
- cell differentiation [IMP]
- cell fate determination [IMP]
- cell fate specification [IMP]
- cell maturation [IDA, IMP]
- cell morphogenesis involved in differentiation [IMP]
- cell proliferation [IMP]
- cell-matrix adhesion [IMP]
- cellular process [IDA]
- cellular protein localization [IMP]
- cellular response to organic cyclic compound [IDA]
- central nervous system vasculogenesis [IMP]
- chromatin-mediated maintenance of transcription [IMP]
- coronary artery morphogenesis [TAS]
- dorsal/ventral axis specification [IMP]
- dorsal/ventral pattern formation [IMP]
- ectoderm development [IMP]
- embryonic axis specification [IDA]
- embryonic digit morphogenesis [IGI, IMP]
- embryonic foregut morphogenesis [IMP]
- embryonic forelimb morphogenesis [IDA]
- embryonic heart tube development [IMP]
- embryonic hindlimb morphogenesis [IMP]
- embryonic skeletal limb joint morphogenesis [IGI]
- endoderm formation [IMP]
- endodermal cell fate commitment [IMP]
- epicardium-derived cardiac vascular smooth muscle cell differentiation [TAS]
- epithelial cell differentiation involved in prostate gland development [IMP]
- epithelial tube branching involved in lung morphogenesis [IMP]
- forebrain development [IMP]
- fungiform papilla formation [IMP]
- gastrulation with mouth forming second [IMP]
- genitalia morphogenesis [IMP]
- glial cell fate determination [IDA]
- hair cycle process [IMP]
- hair follicle morphogenesis [IMP]
- hair follicle placode formation [IGI, IMP]
- heart development [IMP]
- hemopoiesis [IDA]
- in utero embryonic development [IGI, IMP]
- kidney development [IMP]
- layer formation in cerebral cortex [IMP]
- lens morphogenesis in camera-type eye [IMP]
- limb development [IMP]
- lung cell differentiation [IMP]
- lung development [IMP]
- lung induction [IMP]
- lung-associated mesenchyme development [IMP]
- male genitalia development [IMP]
- mesenchymal cell proliferation involved in lung development [IMP]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [IDA]
- mesenchyme development [TAS]
- mesenchyme morphogenesis [TAS]
- metanephros morphogenesis [IMP]
- morphogenesis of embryonic epithelium [IMP]
- negative regulation of apoptotic signaling pathway [IGI, IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of chondrocyte differentiation [IGI]
- negative regulation of mitotic cell cycle, embryonic [IMP]
- negative regulation of neuron death [IGI]
- negative regulation of oligodendrocyte differentiation [IMP]
- negative regulation of osteoclast differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- nephron tubule formation [IMP]
- neural plate development [IDA]
- neuron migration [IGI]
- odontogenesis of dentin-containing tooth [IMP]
- oocyte development [IGI]
- organ development [IMP]
- osteoclast differentiation [IMP]
- oviduct development [IMP]
- pancreas development [IMP]
- patterning of blood vessels [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of MAPK cascade [IGI]
- positive regulation of branching involved in lung morphogenesis [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of determination of dorsal identity [IDA]
- positive regulation of endothelial cell differentiation [IMP]
- positive regulation of epithelial cell differentiation [IMP]
- positive regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- positive regulation of epithelial to mesenchymal transition [ISO, TAS]
- positive regulation of fibroblast growth factor receptor signaling pathway [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of neuroblast proliferation [IGI, IMP]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of telomerase activity [IMP]
- positive regulation of telomere maintenance via telomerase [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- proximal/distal pattern formation [IMP]
- regulation of T cell proliferation [IMP]
- regulation of apoptotic process [IMP]
- regulation of cell differentiation [IDA]
- regulation of cell fate specification [IBA]
- regulation of cell proliferation [IDA, IMP]
- regulation of centromeric sister chromatid cohesion [IMP]
- regulation of epithelial cell differentiation [IMP]
- regulation of gene expression [IMP]
- regulation of myelination [IMP]
- regulation of nephron tubule epithelial cell differentiation [IMP]
- regulation of osteoblast differentiation [IMP]
- regulation of osteoclast differentiation [IMP]
- regulation of secondary heart field cardioblast proliferation [IDA]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [IDA]
- renal inner medulla development [IMP]
- renal outer medulla development [IMP]
- renal system development [IMP]
- renal vesicle formation [IMP]
- single organismal cell-cell adhesion [IMP]
- skeletal system development [IMP]
- skin development [IMP]
- smooth muscle cell differentiation [IMP]
- stem cell maintenance [TAS]
- sympathetic ganglion development [IMP]
- synapse organization [IMP]
- synaptic transmission [IMP]
- synaptic vesicle transport [IMP]
- thymus development [IMP]
- trachea formation [IMP]
- trachea morphogenesis [IMP]
- vasculature development [IMP]
- vasculogenesis [IMP]
- ventricular compact myocardium morphogenesis [TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- alpha-catenin binding [IDA, IPI]
- cadherin binding [IPI, ISO]
- chromatin binding [IDA, IGI]
- double-stranded DNA binding [IDA]
- euchromatin binding [IDA]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- alpha-catenin binding [IDA, IPI]
- cadherin binding [IPI, ISO]
- chromatin binding [IDA, IGI]
- double-stranded DNA binding [IDA]
- euchromatin binding [IDA]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
- Scrib-APC-beta-catenin complex [IDA]
- Z disc [IDA]
- adherens junction [IDA]
- apical junction complex [IDA]
- apical part of cell [IDA]
- basolateral plasma membrane [IDA]
- beta-catenin destruction complex [IDA]
- catenin complex [IBA]
- catenin-TCF7L2 complex [IDA]
- cell [IMP]
- cell projection membrane [IDA]
- cell-cell adherens junction [IDA]
- cell-cell junction [IDA, ISO]
- centrosome [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- fascia adherens [IDA]
- intercalated disc [IDA]
- lamellipodium [IDA]
- lateral plasma membrane [IDA, ISO]
- membrane [IDA]
- microvillus membrane [IDA]
- nuclear euchromatin [IDA]
- nuclear transcription factor complex [IDA]
- nucleus [IDA]
- plasma membrane [IDA]
- protein complex [ISO]
- tight junction [IDA]
- transcription factor complex [IDA]
Mus musculus
PREY
MYC
AU016757, Myc2, Niard, Nird, bHLHe39
myelocytomatosis oncogene
GO Process (67)
GO Function (13)
GO Component (11)
Gene Ontology Biological Process
- B cell apoptotic process [IMP]
- DNA-templated transcription, initiation [ISO]
- MAPK cascade [ISO]
- Wnt signaling pathway [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- amino acid transport [ISO]
- branching involved in ureteric bud morphogenesis [IMP]
- canonical Wnt signaling pathway [ISO]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [IGI]
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process [IGI]
- canonical Wnt signaling pathway involved in positive regulation of wound healing [ISO]
- cell cycle arrest [ISO]
- cell proliferation [ISO]
- cellular iron ion homeostasis [ISO]
- cellular response to DNA damage stimulus [IDA, ISO]
- cellular response to drug [IDA, ISO]
- chromatin remodeling [ISO]
- chromosome organization [ISO]
- detection of mechanical stimulus involved in sensory perception of sound [IMP]
- glucose metabolic process [ISO]
- inner mitochondrial membrane organization [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA, IMP]
- lactic acid secretion [ISO]
- middle ear morphogenesis [IMP]
- negative regulation of cell death [ISO]
- negative regulation of cell division [ISO]
- negative regulation of fibroblast proliferation [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of glucose import [ISO]
- negative regulation of monocyte differentiation [ISO]
- negative regulation of protein binding [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- pigmentation [IMP]
- positive regulation of ATP biosynthetic process [ISO]
- positive regulation of B cell apoptotic process [IGI]
- positive regulation of DNA biosynthetic process [ISO]
- positive regulation of apoptotic signaling pathway [IDA, IMP]
- positive regulation of catalytic activity [IMP]
- positive regulation of cell cycle [ISO]
- positive regulation of cell proliferation [IDA, IGI, ISO]
- positive regulation of cellular respiration [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of glycolytic process [ISO]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of metanephric cap mesenchymal cell proliferation [IMP]
- positive regulation of mitochondrial membrane potential [ISO]
- positive regulation of response to DNA damage stimulus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein processing [IMP]
- pyruvate transport [ISO]
- regulation of apoptotic process [IDA, IMP]
- regulation of gene expression [IDA, ISO]
- regulation of mitotic cell cycle [ISO]
- regulation of oxidative phosphorylation [ISO]
- regulation of telomere maintenance [ISO]
- regulation of transcription, DNA-templated [IGI, ISO]
- response to alkaloid [IMP]
- response to gamma radiation [ISO]
- response to radiation [IDA, IMP]
- skeletal muscle cell differentiation [IMP]
- skeletal system morphogenesis [IMP]
- transcription from RNA polymerase II promoter [ISO]
- transcription, DNA-templated [ISO]
- transformation of host cell by virus [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- E-box binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- core promoter proximal region sequence-specific DNA binding [IDA]
- double-stranded DNA binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [ISO]
- DNA binding [IDA, ISO]
- E-box binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- core promoter proximal region sequence-specific DNA binding [IDA]
- double-stranded DNA binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Androgen signaling is a confounding factor for ?-catenin-mediated prostate tumorigenesis.
Emerging evidence has demonstrated the critical roles for both androgen and Wnt pathways in prostate tumorigenesis. A recent integrative genomic analysis of human prostate cancers (PCas) has revealed a unique enrichment of androgen and Wnt signaling in early-onset PCas, implying their clinical significance in the disease. Additionally, interaction between the androgen receptor (AR) and ?-catenin has long been detected in ... [more]
Oncogene Feb. 11, 2016; 35(6);702-14 [Pubmed: 25893287]
Throughput
- Low Throughput
Additional Notes
- ChIP
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MYC CTNNB1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID