BAIT

LOC100132735

uncharacterized LOC100132735
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Protein-RNA

An interaction is detected between and protein and an RNA in vitro.

Publication

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development.

Xiao ZD, Han L, Lee H, Zhuang L, Zhang Y, Baddour J, Nagrath D, Wood CG, Gu J, Wu X, Liang H, Gan B

The roles of long non-coding RNAs in cancer metabolism remain largely unexplored. Here we identify FILNC1 (FoxO-induced long non-coding RNA 1) as an energy stress-induced long non-coding RNA by FoxO transcription factors. FILNC1 deficiency in renal cancer cells alleviates energy stress-induced apoptosis and markedly promotes renal tumor development. We show that FILNC1 deficiency leads to enhanced glucose uptake and lactate ... [more]

Nat Commun Oct. 04, 2017; 8(1);783 [Pubmed: 28978906]

Throughput

  • High Throughput

Curated By

  • BioGRID