BAIT
VWC2L
von Willebrand factor C domain containing protein 2-like
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
CD36
BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3
CD36 molecule (thrombospondin receptor)
GO Process (27)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- blood coagulation [TAS]
- cGMP-mediated signaling [IDA]
- cellular lipid metabolic process [TAS]
- cholesterol transport [ISS]
- innate immune response [TAS]
- lipid metabolic process [NAS]
- lipid storage [IMP]
- lipoprotein transport [IMP, TAS]
- long-chain fatty acid import [IDA]
- low-density lipoprotein particle clearance [IMP]
- nitric oxide mediated signal transduction [IDA]
- plasma lipoprotein particle clearance [ISS]
- plasma membrane long-chain fatty acid transport [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of cell-matrix adhesion [IDA]
- positive regulation of macrophage derived foam cell differentiation [IMP]
- small molecule metabolic process [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform.
Secreted proteins, which include cytokines, hormones, and growth factors, are extracellular ligands that control key signaling pathways mediating cell-cell communication within and between tissues and organs. Many drugs target secreted ligands and their cell surface receptors. Still, there are hundreds of secreted human proteins that either have no identified receptors ('orphans') or are likely to act through cell surface receptors ... [more]
Elife Sep. 30, 2022; 11(); [Pubmed: 36178190]
Throughput
- High Throughput
Additional Notes
- CRISPR interaction screen
- CRISPR screen
- interaction confirmed by SRP or cell binding
- interaction identified in a CRISPRa/magnetic cell sorting screen
Curated By
- BioGRID